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Posted on 12/10/2025 8:29:55 PM PST by ConservativeMind
Researchers report that a low-dose mixture of zinc, serine, and branch-chain amino acids can alleviate behavioral deficits in three different mouse models of autism. The study shows that when combined together, these three dietary supplements promote communication between neurons in the brain and improve social behaviors.
Autism spectrum disorder (ASD) is known to result from abnormal neural development that affects how neurons are connected. Individually, zinc, serine, and branch-chain amino acids are all thought to have positive effects on neural connectivity.
The authors hypothesized that a mixture of the three would be a more effective treatment than any individually and that the necessary dosages of each could be lowered.
They tested their theory in three mouse models of ASD.
The researchers found that the cocktail of supplements altered the brains of autistic mice so that the expression of proteins in the synapse resembled those of normal mice and that the abnormal hyperactivity of neurons in the amygdala was reduced after taking the cocktail. The researchers also found that social behaviors in the animals improved after they were given the cocktail.
However, when each supplement was given separately, the same dosages had no effect on behavior.
Yi-Ping Hsueh summarized, "As hundreds of genes are implicated in autism, each with distinct molecular functions, a 'one gene–one therapy' approach is impractical for addressing the complexity of ASD.
"Our findings show that a low-dose nutrient mixture containing zinc, branched-chain amino acids (BCAAs), and serine—working synergistically to improve synaptic function and social behaviors across three ASD mouse models—offers a safer and more practical strategy for long-term, broad application, even beginning in childhood."
Ming-Hui Lin, the study's co–first author, added, "I was thrilled to observe that just seven days of treatment with the nutrient mixture significantly modulated neuronal circuit activity and connectivity in real time."
(Excerpt) Read more at medicalxpress.com ...
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They didn’t help at all when taken separately at that same lower dose. Only high doses helped, when taken alone.
How do you determine if a mouse is autistic?
Wait. I thought that you had to be vaccinated to be autistic, or something...
Zinc is good for diabetes as well, because it helps increase the metabolic rate of cells.
how about cleaning up the food system so kids and the people creating them, are not fed so much chemical junk? throwing Rx drugs at symptoms while eating junk filled “food” isn’t the answer.
It would be nice to know what are these “branched-chain amino acids (BCAAs).” So, I went to Dr. Google and this is what they are: the nutrients leucine, isoleucine, and valine. When taken by mouth: BCAAs are likely safe when used in doses of 12 grams daily for up to 2 years. It might cause some side effects, such as fatigue and loss of coordination. BCAAs should be used cautiously before or during activities that require motor coordination, such as driving. BCAA supplements have been linked with lung failure and higher death rates when used in patients with ALS. If you have ALS, do not use BCAA supplements until more is known. I copied and pasted this information.
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