Three deadliest risk factors of a common liver disease identified in new study

Medical Xpress / University of Southern California / Clinical Gastroenterology and Hepatology ^ | Sept. 18, 2025 | Matthew Dukewich et al

[ConservativeMind]

More than a third of the world's population is affected by metabolic dysfunction-associated steatotic liver disease, or MASLD, the most common chronic liver disease in the world.

MASLD occurs when fat builds up in the liver and is associated with one or more of five conditions: obesity, Type 2 diabetes, high blood pressure, high blood sugar and low HDL cholesterol, known as "good" cholesterol. These conditions are characterized as cardiometabolic risk factors because they affect the heart or metabolism.

MASLD can lead to serious illness, such as advanced liver, heart and kidney disease, but little research has been done to examine if certain cardiometabolic risk factors for those with MASLD are more associated with death than others.

Now, a new study reveals that three of the cardiometabolic risk factors carry the greatest risk of death for those with MASLD: high blood pressure, pre-diabetes or Type 2 diabetes, and low HDL, which raise the risk of death by 40%, 25% and 15%, respectively.

These results were independent of how many or which combination of cardiometabolic risk factors patients had and held steady despite individuals' gender, sex, race or ethnicity.

Additionally, the research adds to the growing body of research that patients with more cardiometabolic risk factors have poorer outcomes. The study found that the risk of death in MASLD patients increased by 15% for each additional cardiometabolic risk factor present.

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TOPICS: Health/Medicine
KEYWORDS: liver; liverdisease

[ConservativeMind]

If you have a fatty liver, concentrate first on normalizing your blood pressure, followed by improving your pre-diabetes or Type 2 diabetes, followed by raising your HDL.

Of course, getting rid of your fatty liver could most help. Exercise and weight loss can do that, as can help from pantethine, which I have previously posted on, here.

[ConservativeMind]

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[Freedom4US]

Lose the weight! They list five (5) “risk factors” but they are all different ways of saying Fat, or near enough. Obesity. Non-alcoholic fatty liver.