Arginine dentifrices significantly reduce childhood caries, clinical trial finds (As good as fluoride)

Medical Xpress / Intl Assoc for Dental, Oral, and Craniofacial Res / JDR Clinical & Trans Research ^ | Aug. 13, 2025 | W. Yin et al

[ConservativeMind]

A study demonstrates that arginine dentifrices reduce dental caries in children with active caries as effectively as or more effectively than a sodium fluoride dentifrice, depending on the arginine concentration.

Dental caries remain a significant oral health burden globally. Scientific evidence has demonstrated the dose-dependent, anticaries action of fluoride; however, more effective, comprehensive, and alternative prevention strategies should be investigated.

The study carried out a two-year, phase III, double-blind, three-arm, parallel-group, randomized controlled trial from April 15, 2019 through March 12, 2022 across three centers in China.

Six thousand children aged 10–14 with two or more active caries lesions were assigned one of three study dentifrices: 8.0% arginine, 1.5% arginine, and 0.32% NaF as a positive control. The primary efficacy outcomes were incremental DMFS (decayed, missing, and filled surfaces) and DMFT (decayed, missing, and filled teeth) caries index scores after two years of product use.

After two years, the 8.0% arginine-containing dentifrice demonstrated a statistically significant 26.0% reduction in DMFS and 25.3% in DMFT scores vs. the 0.32% NaF control. No statistical difference was measured between the 1.5% arginine-containing dentifrice and the 0.32% NaF control in DMFS and DMFT.

This clinical study confirms that depending on the concentration, arginine dentifrices are as effective or more effective than a sodium fluoride dentifrice in providing anti-caries protection in children with active caries.

---

TOPICS: Health/Medicine
KEYWORDS:

[ConservativeMind]

Arginine is a easy to find amino acid in powder form.

A small amount worked at least as well as fluoride in preventing cavities.

[ConservativeMind]

The “Take Charge Of Your Health” Ping List
This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

[House Atreides]

Arginine toothpaste, anyone?

[DennisR]

I take an arginine supplement daily.

[Daveinyork]

Can’t they just say toothpaste and cavities?

[ryderann]

https://www.amazon.com/Colgate-Toothpaste-Strength-Protection-Sensitivity/dp/B0DP2GMZK8/ref=sr_1_7?crid=EB1UXI1FW437&dib=eyJ2IjoiMSJ9.SrNpO83Q6O11meeNgPhQ0Ok8ohRgGxo-b07j335Dz70vPkDS5ctOEKABfrCUKKqy1k0VywhoHUxkB4PtFCdTwDpvUsjNn50lMHIy94IxGVKNfsAd2WsOI6KcFuE7wkW1TaGhtQNyxg1ann1MoiTQY3XKRxPuDGEgKc0uigzCZpac62pWrK0o1XZWPHgkTSj1HXSfQESS4IzhzYY-V4VVjCZJPmWHCca1FOFJwotBxWM4d0cskPJRnPX4n00HY2f-Y0-Xlob79R8pgUPAWz1dEMFPPEE7qYWYnJy2qdox6F8.epqe5BEdn53xUO7GLEzQYOp54LkIXyf5Ibeuy759jq8&dib_tag=se&keywords=arginine+toothpaste&qid=1756032613&sprefix=arginine%2Caps%2C1079&sr=8-7=8-7

[sauropod]

Bkkk