Treating your metabolic disease also appears to reverse this problem.
So if your body does not properly metabolize CoQ10, would it do any good to supplement it?
Due to the importance to mitochondrial function, Vitamin D3 and magnesium supplementation are also in order. For the sake of better absorption, the magnesium should be as magnesium glycinate and/or magnesium L-threonate.
There are several different forms of Coq 10- and many c,aims about certain forms being more available absorption wise. I’m not sure what type is considered the best though.
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For my gal - tomorrow. ;-)
Interesting. Thank you.
Unfortunately, not a free article https://pubmed.ncbi.nlm.nih.gov/40437093/ but an earlier paper is here: “Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity”
Abstract: Mitochondrial reactive oxygen species (mROS) are central to physiology. While excess mROS production has been associated with several disease states, its precise sources, regulation, and mechanism of generation in vivo remain unknown, limiting translational efforts. Here we show that in obesity, hepatic ubiquinone (Q) synthesis is impaired, which raises the QH2/Q ratio, driving excessive mROS production via reverse electron transport (RET) from site IQ in complex I. Using multiple complementary genetic and pharmacological models in vivo we demonstrated that RET is critical for metabolic health. In patients with steatosis, the hepatic Q biosynthetic program is also suppressed, and the QH2/Q ratio positively correlates with disease severity. Our data identify a highly selective mechanism for pathological mROS production in obesity, which can be targeted to protect metabolic homeostasis.
https://www.biorxiv.org/content/10.1101/2023.02.21.528863v1.full.pdf
Bkmk
Thanks
BKMK