They are wild animals. I once found myself in the middle of a semi-tamed heard of buffalo, but I remained in the safety of the cab of a pickup truck. Somewhere I have a picture of the herd grazing on a hillside in Wyoming. They were being sort of kept by a rancher who was using them for slaughter.
A buffalo cannot be held in a slaughterhouse. He (or she, the cows are almost as aggressive as the bulls) will demolish the holding pen, the walls of the butcher shop, and level the entire building.
Best way to harvest a buffalo is to have a flat bed truck, with a winch and tilt bed, park about a quarter mile away from the buffalo, and drop it with a heart shot from a 30-06 scoped rifle. The reason you are a quarter mile away is to get a head start if the buffalo is only wounded.
It will be angry.