“Studying cells and animal models in the lab, the authors then showed that GPT1 normally suppressed the formation of tumors from adenomas by producing a metabolic molecule named α-ketoglutarate, which inhibited the WNT signaling pathway, disrupting the metabolically important folate cycle.”
“Regarding poliumoside, the team of cancer biologists found that it reactivated GPT1 and slowed the growth of tumors.”
Alpha-ketoglutarate is available as a common supplement. If this molecule is what triggers GPT1, it might be an option. Poliumoside is also available, but hard to find. It is derived from a Chinese medicinal plant.
Poliumoside was found to slow colon tumor growth in animals by acting on GPT1, which produces alpha-ketoglutarate which disrupts a key pathway that works with folate.
I had a 3 cm polyp removed about 15 years ago.
I’ve had the FIT test a number of times since but not the colonoscopy I very much need to get.
3cm should be followed up by another colonoscopy in a few years, not decades.
I hate that test but I hate dying a slow torturous death more so I need to get on it.
Good article.
Below are displayed all the plants proven (via scientific papers) to contain Poliumoside:
Brandisia hancei
Buddleja officinalis
Callicarpa macrophylla
Cistanche deserticola
Cistanche phelypaea
Digitalis purpurea
Penstemon linarioides
Teucrium polium
I found an extract for Cistanche deserticola at Amazon:
https://www.amazon.com/Cistanche-Extract-10-VegiCaps-Stearate/dp/B00N50K8FE
Xiong concluded. “Deficiency of GPT1 promoted CRC tumorigenesis by rewiring cellular metabolism in enzyme-dependent and enzyme-independent ways.”
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.....Proving once again that, counter to modern medical practice, cancer is a metabolic disease, not a genetic disease. Fix cellular energy pathways and cells stop mutating.