[ConservativeMind]

Creatine is a common workout supplement, but it appears to limit damage to fetuses when starved of oxygen.

[ConservativeMind]

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[tired&retired]

I add it to my morning smoothie and found it very beneficial.

[tired&retired]

Potential Benefits of Creatine for Sleep Apnea

Increased muscle strength and endurance:

Creatine may improve muscle strength and endurance, which could help reduce snoring and sleep apnea episodes.

Reduced inflammation:

Creatine has anti-inflammatory properties, which may help reduce inflammation in the airways associated with sleep apnea.

Improved sleep quality:

Some studies suggest that creatine supplementation may improve sleep quality, including reducing sleep disturbances and increasing sleep duration.

[Pete from Shawnee Mission]

C.M. Thanks! I was told by a trainer that Creatine was developed to help older people to help retain muscle mass, but body builders found it useful so it is pretty much considered a product for weight lifters. It also helps the brain with mood and outlook.

https://pmc.ncbi.nlm.nih.gov/articles/PMC6769464/

Creatine for the Treatment of Depression

3. Conclusions

Creatine is a naturally-occurring organic acid that serves as an energy buffer and energy shuttle in tissues, such as brain and skeletal muscle, that exhibit dynamic energy requirements. Evidence, deriving from a variety of scientific domains, that brain bioenergetics are altered in depression and related disorders is growing. Clinical studies in neurological conditions such as PD have indicated that creatine might have an antidepressant effect, and early clinical studies in depressive disorders—especially MDD—indicate that creatine may have an important antidepressant effect. Future work should, we think, involve larger clinical trials of creatine when used as an adjunctive treatment in MDD, extend to encompass trials of creatine as monotherapy, examine the potential efficacy of creatine as an augmenting agent when combined with neurostimulation techniques such as ECT and TMS, and better characterize the neurochemical and network-level effects of creatine and their correlations with antidepressant response.

[tired&retired]

How creatine helps with hypoxia

Cognitive performance
Creatine supplementation can help with hypoxia-induced cognitive decline, such as decreased attentional capacity.

Muscle damage
Creatine supplementation can help protect the diaphragm of a newborn from hypoxia-induced damage.

Cellular adaptation
Creatine supplementation can increase the cellular adaptive response to hypoxia.

How hypoxia affects creatine
Cardiomyocytes: Hypoxia decreases creatine uptake in cardiomyocytes.

Energy metabolism: Hypoxia interferes with energy metabolism, including the activity of the creatine energy shuttle.

How creatine works
ATP production: Creatine increases phosphocreatine, the major pool for ATP synthesis.

Free radicals: Creatine scavenges free radicals.

Muscle growth: Creatine supplementation can enhance muscle growth.

Acid-base balance: The creatine/phosphocreatine system is involved in acid-base balance.

Contractile function: Creatine decreases ionic strength to improve contractile function.