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Gestational exposure to NSAIDs tied to childhood chronic kidney disease
Medical Xpress / HealthDay / JAMA Pediatrics ^ | Jan. 6, 2025 | Elana Gotkine / You-Lin Tain et al

Posted on 01/21/2025 7:41:58 PM PST by ConservativeMind

Gestational exposure to nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with an increased risk for childhood chronic kidney disease (CHD), although the association is not seen in sibling comparisons, according to a study.

You-Lin Tain, M.D., Ph.D. and colleagues examined the association between gestational exposure to NSAIDs and the risk for CKD in childhood in a cohort study involving 1,025,255 children born alive in Taiwan from Jan. 1, 2007, to Dec. 31, 2017, with follow-up until Dec. 31, 2021.

The study included 163,516 singleton-born children whose mothers used at least one dispensing of an NSAID during pregnancy. The researchers observed a significant association between gestational NSAID exposure and a higher risk for childhood CKD (weighted hazard ratio [wHR], 1.10). In sibling comparisons, there was no association seen between NSAID use and fetal nephrotoxicity. In singleton-born children, increased risks were seen for exposure during the second and third trimesters (wHRs, 1.19 and 1.12, respectively).

Specific NSAID exposures associated with elevated CKD risk included indomethacin and ketorolac in the first trimester (wHRs, 1.69 and 1.28, respectively); diclofenac and mefenamic acid in the second trimester (wHRs, 1.27 and 1.29, respectively); and ibuprofen in the third trimester (wHR, 1.34).

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: kidneydisease; nsaids
For specific NSAID concerns:

“Specific NSAID exposures associated with elevated CKD risk included indomethacin and ketorolac in the first trimester (wHRs, 1.69 and 1.28, respectively); diclofenac and mefenamic acid in the second trimester (wHRs, 1.27 and 1.29, respectively); and ibuprofen in the third trimester (wHR, 1.34).”

1 posted on 01/21/2025 7:41:58 PM PST by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; jy8z; ProtectOurFreedom; matthew fuller; telescope115; ...

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2 posted on 01/21/2025 7:42:26 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Makes sense that if a drug can cause kidney problems in adults, with fully developed kidneys, it could cause serious problems in kidneys developing in a fetus...why do they not look into this kind of effect before the widespread use of these substances?


3 posted on 01/22/2025 5:57:14 AM PST by trebb (So many fools - so little time...)
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