Posted on 01/13/2025 8:37:29 PM PST by ConservativeMind
Researchers have found that intensive blood pressure (BP) control produces cardiovascular benefits and increases the risk of adverse events in people with chronic kidney disease (CKD).
This approach was initially studied in the Systolic Blood Pressure Intervention Trial (SPRINT), a randomized trial with over 9,000 participants. The intervention demonstrated reduced cardiovascular events, mortality, and reduced rates of mild cognitive impairment.
Intensive BP control consisted of treatment with antihypertensive medications to maintain a systolic BP below 120 mm Hg, as opposed to <140 mm Hg, the standard target at the time.
The study included 85,938 VHA patients (75.7 years, 95% male) and 13,983 KPSC patients (77.4 years, 38.4% male). While the eligibility criteria were not modified, the VHA and KPSC populations were inherently different from the SPRINT population due to demographic and clinical characteristics.
VHA and KPSC patients were older on average and included a higher percentage of advanced CKD cases. They also had higher rates of statin use and albuminuria but lower rates of preexisting cardiovascular disease compared to the original SPRINT participants.
Findings revealed that intensive BP control was associated with significant reductions in cardiovascular events and all-cause mortality in both VHA and KPSC populations.
Absolute risk reductions were more prominent in the VHA cohort, with a 5.1% decrease in cardiovascular events at four years compared to a 3.0% reduction in the KPSC group.
Adverse event risks, including acute kidney injury and falls, increased by 1.3% in the VHA population and 3.1% in KPSC. Effects on cognitive impairment and CKD progression were not consistent between trial and target populations.
In patients with advanced CKD, intensive BP control resulted in more significant cardiovascular and mortality benefits but was also linked to heightened risks of heart failure, acute coronary syndrome, dementia, and acute kidney injury.
(Excerpt) Read more at medicalxpress.com ...
I will say I have posted ways to help improve kidney function and there are benign ways to reduce blood pressure, but diet, exercise, and supplements would be needed.
Autoimmune disease has gifted me Stage 2 CKD... proteinuria and hypertension being major symptoms when it’s active. BP meds retain protein in the bloodstream where it belongs so even if my blood pressure is fine I have to take them. Like with a lot of autoimmune disease you pick and choose which risk factor you prefer to deal with, you don’t get a win-win choice.
Best of health to you!
Vigilance…..
Lisinopril ~ derived from the venom of a pit viper...
since the 1930’s, when the propaganda was started about
natural remedies aka ‘snake oil salesmen’. Alternative
rx meds are still synthesized from same venom afaik.
Worse the science for blood pressure tests needs to be
re-visited too. I have noticed my bp tests are rarely
even in the same ballpark no matter how far spaced and
all the other bs precautions. No eat/drink, sit still,
relax, no talking etc.
The nephrologist has me get labs every six months. The autoimmune curse is that our own immune system makes the rogue antibodies that are doing all of the damage. And it’s anybody’s guess what triggers them to go into overdrive. NSAIDs like ibuprofen are suspects. Viruses. Vaccines designed to combat viruses. Anything that prods the immune system could be exciting the crazy part to go on the warpath. It could be any number of common things that are safe for the vast majority of the population.
In my case researchers accidentally discovered the B cell that makes the rogue antibody while treating a leukemia patient. And they can use the leukemia med to kill off those B cells, although they will grow back. It’s way better than broad spectrum immune suppressors.
I get labs every 6 months, too, sometimes more frequently. My GI doc has me on Entyvio infusions every 8 weeks, my hepatologist has me on Tacrolimus for my transplant, plus my pcp takes blood as well. Such is life….🙂
You have to roll with the punches. A year ago I developed some of what I see that you are dealing with, but fortunately for me not as serious. The #1 risk for acquiring a new autoimmune disease is to already have one. I’d just as soon pass on that honor.
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