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DNA sequencing reveals significant decrease in gut bacterial diversity during aging
Medical Xpress / Agency for Science, Tech and Research (A*STAR), Singapore / Nature Communications ^ | Nov. 7, 2024 | Aarthi Ravikrishnan et al

Posted on 11/18/2024 3:58:21 PM PST by ConservativeMind

A new study has revealed that gut bacteria may play a key role in aging, and that specific microbes could be targeted to promote healthy aging.

Aging is a complex, multi-factorial phenomenon with progressive decline in several physiological functions. As Singapore faces a rapidly growing aging population, researchers are seeking ways to understand the aging process and identify key lifestyle and dietary factors to encourage healthy aging.

As part of this effort, the team conducted the first large-scale study on over 200 octogenarians (people aged 80–89) in Singapore. Their investigation revealed how the gut microbiome changes with age, highlighting key microbial species associated with aging, and their potential effects on health.

Using advanced DNA sequencing, the research team discovered a significant decrease in gut bacterial diversity as individuals age. A particularly noteworthy finding was the decline of Faecalibacterium prausnitzii, a crucial bacterium responsible for producing butyrate—an essential short-chain fatty acid that maintains gut health, reduces inflammation, supports gut barrier function, and facilitates gut-brain communication.

Researchers observed an increase in Alistipes and Bacteroides species, with Alistipes utilizing alternative substrates from Bacteroides to generate butyrate. This notable switch may compensate for the reduction of F. prausnitzii, enhancing the metabolic capacity of the elderly gut to produce butyrate and promoting healthier aging.

The team then turned to preclinical models of healthy aging to validate their findings from the human cohort. Despite differences in the microbes present in different host species, the researchers made a surprising discovery that they had remarkably similar functional enrichments, particularly in pathways related to butyrate production. This indicates that although the specific microbes may differ across species, the functional roles they play in fostering healthy aging may be similar.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: aging; bacteria; fiber; gitract; gut
Butyrate is produced by these several species through us eating soluble fiber.

So get enough soluble fiber each day. To age 50, men need 38 grams and women need 28 grams. Keto breads high in fiber are an ideal way to substitute in good fiber. We like Hero and Sola, but there are others that have decent ingredient lists.

1 posted on 11/18/2024 3:58:21 PM PST by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 11/18/2024 3:58:49 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

.


3 posted on 11/18/2024 4:15:00 PM PST by sauropod ("This is a time when people reveal themselves for who they are." James O'Keefe Ne supra crepidam)
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To: ConservativeMind

A study has shown that consuming kiwifruit capsules might be able to increases Faecalibacterium prausnitzii abundance

(More info, at link) …

https://blog.healthmatters.io/2022/01/20/what-is-faecalibacterium-prausnitzii-high-and-low-values-lab-results-explained/


4 posted on 11/18/2024 4:17:41 PM PST by Jane Long (Jesus is Lord!)
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To: ConservativeMind

What if one doesn’t eat breads, except the rare sourdough? Suggestions for soluble fiber?


5 posted on 11/18/2024 4:34:11 PM PST by montag813
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To: ConservativeMind

Bookmark.


6 posted on 11/18/2024 5:26:29 PM PST by Inyo-Mono
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To: montag813

Top 25 Insoluble Fiber Foods and Surprising Benefits Beyond Constipation Relief
https://draxe.com/nutrition/insoluble-fiber/

Top 20 Soluble Fiber Foods + Their Benefits
https://draxe.com/nutrition/soluble-fiber-foods/


7 posted on 11/18/2024 9:00:27 PM PST by stars & stripes forever (Blessed is the nation whose GOD is the LORD. (Psalm 33:12))
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To: ConservativeMind
I will be 77 before the year is out, I take no prescription meds.

But if gut bacteria is the issue, a Good ProBiotic (kept in refrig at drug store, without prescription) is an easy solution.

I don't take them all the time, but if I occasionally take an antibiotic, I take the probiotics for a few days after it. I don't believe it is important to take it all the time. And it is a good idea to give the body a week or so, after and antibiotic.

Another gut treatment? Oatmeal. It stabilizes the gut. I eat a lot of it.

8 posted on 11/19/2024 5:51:25 AM PST by Texas Fossil (Texas is not about where you were born, but a Free State of Heart, Mind and Attitude.)
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To: ConservativeMind

I regularly make my own home made kefir. But I also buy chilled sourkraut you can get in the meat section of giant. also, kimchi from costco.

I don’t eat them everyday but several times a week. Occassionally, I’ll make keto bread. You recommended Hero and sola as keto breads. Where do you get them & what are their ingredients?


9 posted on 11/19/2024 8:00:09 AM PST by ckilmer
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