Posted on 10/02/2024 9:17:48 PM PDT by ConservativeMind
Researchers have discovered a mechanism that drives the long-term decline in immune response that is observed after tuberculosis (TB) has been successfully treated. Their findings suggest a potential new way to restore immune responsiveness and reduce mortality risk after severe infections.
"Sepsis and TB are associated with loss of protective immune responses and increased mortality post successful treatment," said Dr. Andrew DiNardo. "In the current study, we investigated what mediated the perturbation of immune function after severe infections."
Researchers know that severe and chronic infections in humans and animals result in persistent, long-lasting epigenetic changes. These changes refer to alterations in chemical markings on the DNA that tell cells in the body which genes to turn on or off.
TB dampens immune responsiveness by adding extra methyl chemical tags (DNA methylation) to certain genes involved in immune responses. This results in decreased production of proteins mediating immune defense and increased susceptibility to infections.
Previous studies have identified the tricarboxylic acid (TCA) cycle, a key part of cellular metabolism, as a metabolic driver of the epigenetic landscape in cancer. DiNardo and his colleagues wanted to see if TCA also regulated epigenetics, specifically DNA methylation, after infection-induced immune tolerance.
The team reported that human immune cells treated in the lab with bacterial lipopolysaccharide, a bacterial product, and Mycobacterium tuberculosis, the bacteria that causes tuberculosis, became immune-tolerant. They also found that patients diagnosed with both sepsis and TB have increased TCA activation, which correlates with DNA methylation.
When TB patients were given the standard care of therapy and antibiotics, plus everolimus, an inhibitor of TCA activation, the damaging methylation changes to their DNA were reduced, which suggests that it can help restore the immune system after severe infections.
"What we found is going to lead to a paradigm shift," said Dr. Cristian Coarfa.
(Excerpt) Read more at medicalxpress.com ...
This drug is available today and is used to help with organ transplants and some cancers.
Start taking Vitamin C! Take Vitamin D, too! Then take a balanced form of copper and zinc. All that will charge up your immune system in no time.
Wow!
The cost works out to be $702 per tablet for the 5mg, 7.5mg, and 10mg strength tablets. The 2.5mg strength is slightly cheaper at $671 per tablet.
However, most people will not have to pay this much because insurance plans should cover most of the cost of this medicine, although it is not covered by Medicare.
https://www.drugs.com/medical-answers/afinitor-cost-month-3539995/
Actually, with anyone using the free GoodRX discount code, it can be as little as $2 a pill for the generic at 0.5 mg each, or $120 a pill for the generic at 5 mg each.
I didn’t dig into the study to see what dose was needed.
After research wherein I found a study showing that a number of common cancers completely lacked zinc in the cancerous tissue, even when it was plentiful in their normal tissues, I added more zinc to the supplements my 2 cancer victims were taking. One of the researchers in that study suggested a trial using zinc and an “ionophore” I had never heard of. I had the ionophore Quercetin I bought at Walmart and increased their dose of that as well. I also added Astaxanthine after I read an article saying it lowered the live span of cancer cells while it increased the life span of normal tissue. so I added that. My partner is now cancer free (prostate) and also had 6 weeks of radiation and anti-testosterone shots. My brother with metastatic liver cancer was doing well with chemo and his supplements until he had his 4th Covid shot, whereupon his cancer became VERY vigorous and rapidly deadly.
Those covid injections are really good at turning normal cancer into turbo cancer!
I react very poorly to quercetin. I just tried some yesterday, a very small amount. Nope.
When I first tried it years ago it did help a lot, but after taking it for a few months, I started reacting to it, like everything else I try. >:(
I make sure to take zinc daily.
Acquired Hemophilia A after SARS-CoV-2 Immunization: A Narrative Review of a Rare Side Effect
It sounds as though you might have more success if you took one item for a few weeks, then shifted to something also effective for another short span, then to a third if available. There are a number of ionophores that can help get zinc into virus infected cells. Quercetin is only one of the over the counter ones. Also EGCG, derived from green tea, and to a lesser extent Resviratrol derived from red wine. HCQ and Ivermectin are ones that require a doctor’s prescription, or a handy farm supply store for the Ivermectin, where I was assured it should only be used for horses, but was not prevented from buying.
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