It would seem there is a 67% chance it would reduce it for others with uncontrolled blood pressure.
A 5% drop from 180 would take off 9 mm Hg (points).
They failed to give specifics on the genetic variants so that those of us who have a DNA test can look it up. I hate it when articles do this. But at least I know this is something I need to research
So the question then becomes, “Does reducing the blood pressure from 180 to 170 actually decrease heart attacks, strokes or reduce total mortality?”
Back when my systolic blood pressure was 155, Valsartan would drop it to 125 - a very unusual amount. Micardis dropped it to 148 (about 5%). The military could get Micardis cheaper, so they gave that to me instead. Nothing quite like government health care!
I could understand taking Valsartan, but figured Micardis wasn’t worth the effort.
The good news was going to Keto and losing a bunch of weight has, eventually, dropped my systolic to the upper 120s without medicine.
Super Beets did the trick for me.
A few years back, Howie Carr used to run ads for it on his radio show.
I gave it a shot and my BP went from the 150s to the 120s and below.
Bkmk
The article is about very specific genetic cases, while there are a number of conditions that lead to “uncontolled” (I call is medicine resistent) hypertension, most of which have zero, zip, zilch to do with fluid retention.
Arteries (or an artery) to the kidnies (or a kidney) that is blocked or has a restricted flow can cause nerve-information signals that become treated as a demand for more blood pressure.
A faulty thyroid that results in hypothyroidism can cause changes that result in higher blood pressure.
Some issues with the adrenal glands can cause chemical imbalances that cause higher blood pressure.
A neck injury that injurs or upsets a group of nerve sensors (baroreceptors) along the carotoid arteries can cause extremes in blood presssure.
Bradycardia - low pulse/heart rate, is now known to possibly cause high blood pressure.
Just to name a few.
Fluid retention is very old school when it comes to trying to regulate blood pressure.
I had high blood pressure and for the first time in quite a few decades no longer take any diuretic and have vastly, vastly reduced doses of two other meds, with no lingering high blood pressure, after we got a pacemaker that got rid of the bradycardia. I can now eat all sorts of very salty things with no noticeable affect on my blood pressure at all - because fluid retention was never really the problem.
Also, many doctors see “fluid retention” in the ankles and feet of someone with high blood pressure and assume it is blood vessel related, when often is not blood vessel related but lymphatic and diuretics usually can’t do much about that.