Posted on 09/16/2024 8:46:35 PM PDT by ConservativeMind
In a study, Dr. Shai Bel and his research team have uncovered crucial insights into how antibiotic use increases the risk of inflammatory bowel disease (IBD).
The study demonstrates that antibiotics interfere with the protective mucus layer in the intestine, a discovery that could reshape our understanding of antibiotic effects and IBD development.
IBD, which includes Crohn's disease and ulcerative colitis, affects approximately 1% of the global population. This debilitating condition is marked by the erosion of the mucosal layer that serves as a critical barrier between the gut microbiome and the immune system.
Despite ongoing research, the exact causes of IBD remain unclear. However, previous studies have indicated a link between antibiotic use and an increased risk of developing IBD.
Dr. Bel's latest research sheds new light on this association. "We have discovered that antibiotic use actually damages the protective mucus layer that separates the immune system in the gut from the microbiome," says Dr. Bel. His team's study reveals that antibiotics, whether administered orally or via injection, disrupt this vital mucus layer, facilitating bacterial penetration and increasing the risk of gut inflammation.
Utilizing advanced techniques such as RNA sequencing, machine learning, and mucus secretion measurement, the researchers examined the effects of antibiotics using mice models. The study found that antibiotics hinder the secretion of protective mucus, leading to bacterial infiltration, systemic bacterial antigen replication, and ulcer development—hallmarks of IBD.
One of the most striking findings of the study is that antibiotics' impact on the mucus barrier is not due to alterations in the microbiome but rather affects the cells in the intestinal wall responsible for mucus production. "This finding shatters the paradigm that antibiotics harm only bacteria and not our own cells," Dr. Bel explains.
(Excerpt) Read more at medicalxpress.com ...
It’s like a double-whammy getting rid of protective gut mucus.
I can say I had a week long course of antibiotics late last year, and I had ongoing gut pains until just a couple months ago. Probiotics weren’t enough. Lots of soluble fiber and adding in manganese with taurine seemed to finally fix everything up. I recently posted a study that found manganese helps with this very problem, but I started taking it for a completely different reason.
Its not just that, it wipes out good bacteria as well.
You need to take probiotics when you take antibiotics, and then take them afterwards, to replenish good bacteria, preferably enteric coated capsules so they can survive the stomach and colonize in the intestines.
They knew this way back. They used to prescribe probiotics with people on antibiotics.
So, any suggestions on how to restore that lining or gut health?
Every time I’ve had to take a course of antibiotics I got a bad case of the “runs”!, if you know what I mean
Didn’t get back to my elimination habit for a month.
I hate Immediate Care Clinics, and I hate c.diff infections.
RIGHT! Al they had to do was ask me, lol! Hey, do you think I could get some of that grant money? /s
Well, I had forgotten about the following study I had posted.
https://freerepublic.com/focus/f-chat/4181921/posts
About five months ago, I also started taking 22 mg of zinc picolinate, but for my prostate. This, too, appears to have helped, according to the study at the link.
The keyword “IBD” has more to consider.
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