Chinese medicinal fungus shows promise in treating idiopathic pulmonary fibrosis

Medical Xpress / Sichuan Intl Medical Exchange and Promotion Assoc. / MedComm – Future Medicine ^ | July 26, 2024 | Ying Zhang et al

[ConservativeMind]

A study from China has reported that Cordyceps sinensis (CS), a traditional Chinese medicinal fungus, can ameliorate idiopathic pulmonary fibrosis (IPF) in mice by inhibiting mitochondrion-mediated oxidative stress.

Idiopathic pulmonary fibrosis is a chronic and progressive lung disease characterized by a decline in lung function, ultimately leading to respiratory failure and a significantly reduced quality of life for patients. With a median survival duration of two to five years post-diagnosis, there is an urgent need for effective treatments beyond the current anti-fibrotic medications, which are associated with adverse effects.

The study details how CS, known for its antioxidant and anti-inflammatory properties, was found to mitigate pulmonary inflammation and collagen deposition in a mouse model of IPF.

Proteomic analysis revealed that CS's therapeutic effect may be attributed to the regulation of mitochondrial oxidative phosphorylation, suggesting a potential protective mechanism against IPF.

The research team's findings indicate that CS not only reduces the production of mitochondrial reactive oxygen species (mitROS) but also mitigates oxidative stress and inflammation by targeting mitochondrial complexes I and II.

These mechanisms contribute to the therapeutic effect of CS in pulmonary fibrosis, offering a promising alternative for patients suffering from this debilitating disease.

The study concludes that CS has the potential to be a novel therapeutic agent for IPF, with its effects validated through both in vivo and in vitro experiments. However, the authors acknowledge the need for further research to identify the specific components in CS responsible for its therapeutic effects and to elucidate the detailed mechanisms of its action.

[ConservativeMind]

Cordyceps sinensis is one variety of cordyceps. This specific form, dried, is available in supplements, with NOW Foods making one such product.

This is a bad disease and it looks like there could be some relief available.

[ConservativeMind]

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[curdogmen]

wow thank you sooooo much for that information...best news thank GOD

[OftheOhio]

I’m on year six...Absolutely refusing to take Nintedanib is one of the reasons. This I may very well try.

[OftheOhio]

One of the most horrible things about the disease is the fear of not being able to catch your breath and is called Dyspnea.
I attribute getting IPF from the antibiotic Sulfamethoxazole.

[Track9]

I think Ivermectin is also derived from a fungus.

[z3n]

[ConservativeMind]

That would both scare me, and drive me crazy.

I have a friend with COPD. He’s been on oxygen, for years.

[NorthMountain]

According to wikihahahahapedia, ivermectin is derived from certain soil bacteria.

But wikihahahahahapedia also says that ivermectin is no good for treating the wuhan virus, so I’m not sure that I can trust anything in that article ...

[OftheOhio]

You automatically get COPD when you have IPF. Another thing my pulmonologist didn’t tell me.