Ha! I recently had to get a new desktop & of course, had to get Windows 10. I asked the computer guy if there was an anti-virus program he recommended. He said Windows Defender was as good as anything else on the market. Oh well...
Defender is at least as good overall as any of the third-party add-on packages whose names you recognize (McAfee, Norton, etc.).
One you might not recognize because it is primarily an enterprise product is CrowdStrike Falcon. There's a version of it available for home/small-business use, around $60:
I have not used the home/small-business product myself. But I use the enterprise version at work in my role in IT and it's very good. So I'll suggest taking a look at that.
Personally, at present I'm using Windows Defender and MalwareBytes, but I'm considering Falcon Go for future use.