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Researchers determine timing is key for type 2 diabetes drug performance (Take metformin 30-60 mins before meal)
Medical Xpress / University of Adelaide / Diabetologia ^ | June 7, 2024 | Rhiannon Koch / Cong Xie et al

Posted on 06/16/2024 8:41:40 PM PDT by ConservativeMind

Researchers could be closer to discovering a better way to use metformin, a common type 2 diabetes medication.

Metformin is typically taken with meals to reduce gastrointestinal side effects, but new research is suggesting patients could see improved results if it's taken before meals.

Dr. Cong Xie and a team which studied the gastrointestinal effects of the drug on 16 people living with type 2 diabetes who were already using it to treat the condition.

Their findings were published and are now being used in e-learning by the European Association for the Study of Diabetes (one of the largest international platforms for diabetes research and clinical practice).

"Our results demonstrate administering metformin 30 to 60 minutes before a meal reduces plasma glucose levels while increasing the secretion of the incretin hormone glucagon-like peptide 1 (GLP-1) and insulin levels," Dr. Xie said.

"GLP-1 is a hormone secreted from the gut, which exhibits several actions, including the suppression of appetite, stimulation of insulin, slowing of gastric emptying and the subsequent glucose absorption in the intestine, all of which are beneficial for the control of blood sugar and body weight.

"A number of GLP-1-based drugs are now used clinically for the management of obesity and type 2 diabetes."

Dr. Xie said the plasma GLP-1 levels increased only when metformin was given before the subjects were given a glucose infusion and not at the same time.

"This suggests the levels are affected by changes in the glucose-gut interaction," he said.

Associate Professor Wu said the study found there was no real difference to the nausea scores of patients between the administration times.

"The findings of our study suggest that the empirical recommendation for ingestion of metformin with meals may have compromised its efficacy to improve blood glucose control after meals," he said.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: metformin; type2diabetes
Taking metformin 30-60 before a meal provided better after meal blood glucose, insulin, and GLP-1 benefits.

They found no issues with nausea, taking it during this earlier time.

Sounds worth trying.

1 posted on 06/16/2024 8:41:40 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

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2 posted on 06/16/2024 8:42:22 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

This information is of some importance to me. Thanks for posting!


3 posted on 06/16/2024 8:55:38 PM PDT by Leaning Right (The steal is real.)
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To: ConservativeMind

While I’m sure the info is accurate, it’s rather sad that it this long to figure it out. Seems like a people are asleep at the wheel.


4 posted on 06/16/2024 9:18:45 PM PDT by BobL
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To: ConservativeMind

Wonder how that works if the Metformin is time released?


5 posted on 06/16/2024 10:32:06 PM PDT by FreedomNotSafety
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To: ConservativeMind
They found no issues with nausea, taking it during this earlier time.

LOL! They didn't ask ME !!! Was never so relieved as when my doctor put me on injected insulin and let me stop taking Metformin. Stuff left me feeling like I'd swallowed an industrial floor cleaner unless I followed up instantly with a full meal.

6 posted on 06/16/2024 11:39:56 PM PDT by Chad C. Mulligan
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To: ConservativeMind

16 people is not a real big study, but it’s worth a try. Thanks for posting it.


7 posted on 06/17/2024 5:57:01 AM PDT by Carriage Hill (A society grows great when old men plant trees, in whose shade they know they will never sit.)
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