Posted on 05/17/2024 10:03:40 PM PDT by logi_cal869
A strict "keto-friendly" diet popular for weight loss and diabetes, depending on both the diet and individual, might not be all that friendly.
A new study led by researchers at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) found that a continuous long-term ketogenic diet may induce senescence, or aged, cells in normal tissues, with effects on heart and kidney function in particular. However, an intermittent ketogenic diet, with a planned keto vacation or break, did not exhibit any pro-inflammatory effects due to aged cells, according to the research.
The findings have significant clinical implications suggesting that the beneficial effect of a ketogenic diet might be enhanced by planned breaks.
"To put this in perspective, 13 million Americans use a ketogenic diet, and we are saying that you need to take breaks from this diet or there could be long-term consequences," said David Gius.
Gius is lead author of the new study titled, "Ketogenic diet induces p53-dependent cellular senescence in multiple organs," published May 17 in the journal Science Advances.
(Excerpt) Read more at medicalxpress.com ...
Scientifically, it would be interesting to learn what percentage of CKM syndrome patients are engaged in this fad. I have many more questions...
But my experience demonstrates that there will be some rather emotional responses to this study.
Who paid for the study?
Clearly not the same sources who paid for all the pro-keto studies and mass-propaganda campaigns.
/s
>> Who paid for the study?
JUST STOP injecting rational thought into this hyperbolic spacecraft launch!
And just who would those be?
Well, they fed the mice a Crisco based high fat/protein diet
As anyone with real experience in Keto, you do not eat shit oils or fats. Particularly htdrigenated ones.
As usual. The study is useless because the lab diet isn’t an actual keto diet that a human would eat.
As anyone with real experience in Keto, you do not eat shit oils or fats. Particularly htdrigenated ones.
Speaking of oils.....
Dr. Berg - This Is One of the WORST Things You Can Eat
https://www.youtube.com/watch?v=NJFOF_VEwFs
>> this fad
Keto is generally considered a super-low carb diet. Why the ridicule given low carb diets are essential for those with diabetes?
Periodic fasting
Or intermittent fasting
You are conveniently lumping T1 & T2 together.
My comment addresses T2 & keto
Aw, c’mon man.
You and I both know full well that the orthodox medical establishment’s business model is to keep us all chasing our tails and intermittently crawl back to them when our plethora of home remedies and ‘diet’s fail us.
Practically zero has been gleaned from any studies thus far which are panacea.
If they were, subscribers to Medical Xpress would be the healthiest people on the planet. /s
This post is merely a counter to all the ‘pro-keto’ garbage which preceded it, and it’s HARDLY in balance.
Take it or leave it, but a bunny hole of research funding will not be my weekend, and nothing...absolutely NOTHING will change my opinion of keto or any of the other ‘diet’s, let alone the orthodox medical establishment or this rigged mechanism they call ‘scientific/medical studies’ in this country. Frankly, I was shocked to see a negative keto study.
*SHOCKED* /s
Someday I may publish [perhaps] and then it will all be crystal clear.
ps...There’s more than one reason the government is keen to importing millions of working age people while simultaneously seemingly hellbent upon making us die sooner, but I chose not to write that book and paint a target on my back (and more than one reason I’m reluctant to publish my health books).
Define “Keto”.
Just because it’s low-carb high fat, doesn’t make it healthy. Yes, the kinds of fats matter. But these anti-Keto studies never reveal the kinds of fats their subjects ingest.
Not an intentional generalization, but T2 was the intended factor which I happen to have.
My A1c is now less than 6.5 due to the virtual elimination of carbs. It’s a struggle.
I paid a serious price for being too relaxed about the carb intake. So I’m not arbitrarily calling this article into question.
Because cellular senescence has been implicated in organ disease, including in the heart and kidneys (27–29), we assayed for a widely used biomarker, senescence-associated β-galactosidase (SA-β-gal) and found a significant increase after both 7- and 21-day KD in the heart (Fig. 1C), kidney (Fig. 1D), liver (fig. S1B), and brain (fig. S1C), compared to control. To verify that the apparent increase in cellular senescence was caused by KD, and not by a specific diet composition, including the percentages of saturated versus unsaturated fatty acids, we put mice on a cocoa butter–based KD from Research Diets Inc. (90% calories from fat, 10% from protein, and 0% from carbohydrate), with roughly 40% unsaturated fatty acids and 60% saturated. For this experiment, control mice were put on a protein-matched diet also from Research Diets Inc. (10% calories from fat, 10% from protein, and 80% from carbohydrates) (Table 1). Both the control and KD were fed ad libitum, and no difference in body weight was observed between the two groups over 21 days (fig. S1D).The research appeared sound at my cursory look, more so as I ...well, actually read paragraphs pertinent to your comment.
Done now. How right I was. /s
90% of calories from fat is way too high. It should be more around 70-75% of calories from fat.
Although I have modified my diet to increase the amount of protein and lowered the fat-percentage of calories. As I have read it’s more important that older people increase protein intake.
I must vehemently disagree.
After I navigated my health hell and healed, I now enjoy a rounded diet which includes all manner of healthful carbs. That pattern has persisted now for over 10 years.
(note the key word, coupled with 'after healed')
My understanding is, you can either eat a high carb/low fat diet, or a low carb/high fat diet. What you cannot do, and sadly what most do, is a high fat/high carb diet.
In a way it makes sense, because back in early days, your diet was dictated by where you live. In some places only foods high in carbs were available with little availability of animal-based proteins, and other places where animal-protein was available but vegetation, especially in winter months wasn’t available.
I wonder if intermittent or periodic fasting (autophagy) gets rid of those accumulated (aged) cells.
What’s the one thing? I like Dr Berg, by the way, and subscribe to his channel.
I’m more interested in whether - like T2 diabetes - CKM syndrome is correctable by diet & lifestyle changes.
But I seriously doubt that research will come from domestic sources.
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