Yes, but.
Bear bones are reputed to be hard and thick. Some people suggest that expandable self defense loads for human targets will expend their energy too soon, not drill deeply, deflect, or break up. Those people strongly suggest hard cast lead bullets, among which is Buffalo Bore.
The only thing it's really known for, beside the infamous “Jersey Devil’’ is cranberry bogs.
Some years ago someone in the NJ Division of Wildlife or what ever thought it would be a great idea to introduce black bears into ''The Pines''. The cranberry farmers went nuts and the idea was abandoned.
Many a griz has been taking down by a Colt “Peacemaker” and similar - hard cast bullets.