When is the last time 100,000 people got killed or badly hurt EVERY YEAR in airplane crashes? In north America cars do that every year. SIZE MATTERS.
A single car crash may end the life of 1,2, or 5 people. A single aircraft crash can end the life of 250+ people.
Different steps are taken to avoid each. A wheel coming off a car is a problem that might have deadly consequences. It's normally a sign of improper installation by an amateur. A wheel falling off a commercial airliner, from a major carrier in a formerly first world country, is a sign of a very serious problem.