Posted on 01/22/2024 8:52:10 PM PST by ConservativeMind
A study shows efficacy and safety of oral antibiotic therapy, in the form of pills, for Staphylococcus aureus bloodstream infections. Currently, infusions are the standard treatment.
An international clinical trial led by Professor Dr. Achim Kaasch was able to gain decisive new insights into the treatment of bloodstream infections with the pathogen Staphylococcus aureus (SAB).
The research shows that in patients with a low risk of developing infectious complications, an early switch to oral antibiotic therapy is as effective and safe as continuing the intravenous standard treatment.
This therapy approach enables easier treatment and faster discharge from hospital for patients.
The bacterium Staphylococcus aureus is one of the most common pathogens worldwide, which can cause severe bloodstream infections—also called sepsis or blood poisoning. An estimated 30,000 people in Germany fall ill each year from this infection alone, and about 25 percent of those affected die within the first three months.
Professor Kaasch explained, "If SAB is not adequately treated, there is a serious risk that the infection will spread to other parts of the body. Even after successful treatment, an infection can often have a negative effect on the recovery process for several months."
The standard intravenous treatment of SAB with antibiotics is carried out in hospital for at least 14 days. The research group focused on the question whether oral therapy with pills is as effective as conventional intravenous treatment in patients with SAB.
"We found that an early switch to oral antibiotic therapy after five to seven days of intravenous treatment is as safe and effective as the established standard intravenous therapy," said Kaasch.
Nevertheless, according to the microbiologist, a careful assessment of patients for signs and symptoms is necessary to clarify whether infectious complications already exist. Only if these are excluded can oral switch therapy be considered.
(Excerpt) Read more at medicalxpress.com ...
Switching to oral antibiotics after five to seven days of intravenous delivery for less complicated infections works for me.
Wish they would indicate what antibiotics seem to be the best for fighting this.
In the General/Chat forum, on a thread titled Study finds early switch to oral antibiotic therapy for S. aureus bloodstream infections is safe, effective (Leave the hospital days earlier), Secret Agent Man wrote: Wish they would indicate what antibiotics seem to be the best for fighting this.
Two possible resources below.
1) What is the oral antibiotic for Staphylococcus aureus?
Some experts recommend combination therapy with a penicillinase-resistant penicillin or cephalosporin (in case the organism is methicillin-sensitive S aureus [MSSA]) and clindamycin or a quinolone. Others suggest use of clindamycin, trimethoprim-sulfamethoxazole (TMP-SMX), rifampin, doxycycline, or a quinolone.Jul 27, 2021
Staphylococcus Aureus Infection Treatment & Management
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2) Note that Frontline Doctors have several protocols for things like RSV or flu, or in this case, Sepsis. Here's their protocol (one for hospital - one for home). You can download or print it. :D
https://covid19criticalcare.com/protocol/sepsis-care/
Bkmk
Yep - but they get so much more money when they do the intravenous method - hospitals will resist this common sense money-saving solution.
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