Posted on 12/17/2023 9:18:03 PM PST by ConservativeMind
Aging poses a number of challenges to the body's well-being, one of the most important being an increased susceptibility to multiple diseases, including urinary tract infections (UTIs). The connection between aging and more prevalent UTIs is not well understood, but now researchers have found an explanation.
Compared to the younger counterpart, the aging urinary tract in animal models changes how it functions at the cellular level in ways that seem to favor the establishment and recurrence of UTIs.
Furthermore, the researchers also found that the sugar D-mannose reduces the severity of aging-associated decline in urinary tract functionality, suggesting that this common, over-the-counter supplement could improve this age-associated dysfunction and help reduce UTIs.
"We began this study by comparing the functions of naturally aging cells in mouse bladders with those of younger animals," said Dr. Indira Mysorekar.
The researchers investigated a process called autophagy that all cells naturally use to clean up old or defective cellular materials by digesting and recycling them in structures called lysosomes. "We found that the recycling process naturally slows down as urothelial cells age," said Mysorekar.
"Older cells accumulate larger lysosomes that are less effective at degrading cellular materials, which leads to their toxic accumulation inside the cell."
Aged urothelial cells also accumulate more damaging reactive oxygen species (ROS) than younger tissues.
"Consequently, an inflammatory process builds up, leading to cell death. Dead urothelial cells leave their location, exfoliating the bladder and disrupting its integrity, which further exacerbates age-related dysfunction."
Importantly, they also discovered that treating aged mice with D-Mannose, a natural sugar, restores autophagy and mitigates ROS and urothelial cell shedding, suggesting that mannose supplementation could counter age-associated human urothelial dysfunction.
(Excerpt) Read more at medicalxpress.com ...
If you are taking Jardiance or Farxiga to control blood glucose you are increasing kidney secretion of glucose into your urine.
That’s the banquet dinner bell for UTI bacteria.
D-Mannose prevents them thar bugs from sticking to your urinary tract.
Cheap. Effective. I’m taking it, I’ve got my mom taking it.
I tried to get a friend to use D-Mannose years ago for her recurring UTIs...I think she thought it was quackery. Dr. Wright of Tahoma Clinic has been recommending it for YEARS.
*bump*
Have a family member who might be interested in this.
Tell her nully recommends it...
Haha...yeah...she also has bought into the vaxes...and I understand is dealing with kidney failure problems now...
Tell her nully recommends avoiding it at all costs...
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