Real-world analysis of sodium-glucose cotransporter-2 inhibitors in kidney transplant recipients

Medical Xpress / American Society of Nephrology / ASN Kidney Week 2023 ^ | Nov. 4, 2023 | Anwar Nageen, MD et al

[ConservativeMind]

Sodium-glucose cotransporter-2 (SGLT2) inhibitors lower blood sugar levels and have additional beneficial effects on kidney and heart health for individuals with and without diabetes, but little is known about the safety and efficacy of these medications in kidney transplant recipients. Research that examined this will be presented.

For the study, investigators analyzed the electronic medical records of 3,450 adult kidney transplant recipients treated with SGLT2 inhibitors who were matched to 3,450 similar patients who did not receive SGLT2 inhibitors, using a statistical technique called propensity matching adjusted for demographic data, baseline heart disease and blood test.

Kidney transplant patients treated with SGLT2 inhibitors were 59%, 64%, 33%, and 40% less likely to experience kidney transplant rejection, kidney transplant failure, major adverse cardiac events, and mortality, respectively, over 3 years. They were also 44% less likely to experience urinary tract infections.

"To date, all major SGLT2 inhibitor studies have excluded kidney transplant patients. This study was the largest observational study demonstrating the benefits of SGLT2 inhibitors in patients with kidney transplants," said Nageen, Anwar, MD.

"This study is a big step towards qualifying transplant patients to benefit from the many positive effects of SGLT2 inhibitor use and sets the precedence for a randomized controlled trial to evaluate the long-term kidney and cardiovascular outcomes of SGLT2 inhibitor therapy in kidney transplant patients."

[ConservativeMind]

This new class of drugs seems to help set one’s health in a positive direction, which is especially needed with transplant patients.

SGLT2 inhibitors are available today.

[ConservativeMind]

The “Take Charge Of Your Health” Ping List
This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

[Mark]

Thank you all very much for your birthday wishes! I had a great day and a great birthday dinner (T-bone steak)!
God bless,
Jim

To ALL, let’s get this Freepathon over before Thanksgiving and double the contributions. Robinson family needs help due to health issues.