Posted on 11/02/2023 5:48:04 PM PDT by ConservativeMind
A study in mice proves that exposure to contaminating mixtures of metals and drug residue increases damage to health, and evaluates the positive effects of a diet enriched in selenium to reduce this harm. toxicity.
To understand the health effects of exposure to these "cocktails of contaminants," a team evaluated, in mice, the toxicity of a mixture of contaminants that is common in the environment and that accumulates along the food chain: a combination of metals (arsenic, cadmium, mercury) and drugs (diclofenac, flumequine).
Their conclusion is the cocktail effect creates synergy between these compounds, doing increased damage to health when the compounds act together.
"We used a massive protein detection technique (shotgun proteomic)," April explained.
Of proteins affected, they selected 275 as sentinels to verify what was changing and, after computer analysis, they were able to determine the metabolic pathways that were altered and their consequences for health. These analyses revealed a disproportionate defense response having a contrary and harmful effect on the system.
The researcher stressed that "although these pollutants generated oxidation in the cells separately too, when they acted together we found that the oxidation was so intense that all the antioxidant defense responses were activated continuously, without deactivating them, which ends up doing damage and causing many proteins to stop working."
The analyses showed a sustained expression of the response mediated by NRF2, which is the regulator that sets in motion a good part of the antioxidant defenses, which caused a reducing stress.
The study also provides hope, as selenium could be a way to reduce the damage caused by exposure to these pollutants. A third group of mice were given doses of selenium, a mineral often found in vitamin supplements found in pharmacies, and proteomic analyses showed relief from the molecular damage done by the pollutants.
(Excerpt) Read more at medicalxpress.com ...
Also its important to note if where you live has soil that is selenium deficient, because any veggies you get locally will be low and you may need to supplement. Where I am our soil is, and many people here in the state are deficient in selenium.
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Gives ya really bad breath if you take too much though.
Right under sulfur on the Periodic Table.
Sulfur says “I’m the nasty in everything bad you’ve ever smelled.”
Selenium says “Hold muh beer.”
A brazil nut a day has our selenium.
Brazil Nuts.
If that is the rda value, those are notoriously low and under-estimated for many vitamins and minerals.
I guess I need to research it more. Thanks, I have been eating them for quite awhile now. Our soil in Michigan is deficient. We also raised dairy goat for 25+ years. We gave them trace minerals mixed in with their grain and selenium was an ingredient. Without selenium they are subject to white muscle disease, so we always knew it probably affected us in some way in our homegrown veggies.
I’m next door to you, basically the midwest around the lakes is deficient.
I eat 5g of Brazil nuts daily. However most Brazil nuts come from Bolivia and apparently have less selenium than those from Brazil.
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