So for those that don’t really understand how genetics make a huge difference on this...this paragraph is an example. btw, I saw a study that indicated that it seems that people who have retina issues with this drug had a higher level of one of the metabolites...which could be related to genetic breakdown of the drug
“So, in the present study, CYP2D6*4 (AA) carriers were poor metabolizers and HCQ was metabolized poorly leading to decreased formation of one of the active metabolites (desethyl HCQ), this could decrease the efficiency of HCQ in preventing Covid-19 viruses from entering cells making the risk of Covid-19 infection and formation of IgM antibodies more likely.”
Here is the other thing you need to know if you have your DNA.
Throughout the lockdowns I was very cautious because I knew I had some strange issues and really wasn’t sure how COVID would effect me. That is before I learned all about P450 enzymes.
If you have this variation just proceed with caution if you get COVID and act fast.
“Also, the levels of desethyl HCQ might be lower in carriers of CYP2D6*4 (AA) leading to a significant difference in the grade of ground glass opacities in the chest CT where CYP2D6*4 AA were the only patients who had grade 3 ground glass in the chest CT and the only admitted to ICU. CYP2D6*4 AA carriers also showed more hospitalization ratios vs. wild and heterozygous carriers (but p-value was >0.05).”