I had to look up to find the drugs in each class:
Warfarin, the most frequently used oral VKA in the United States, inhibits the vitamin K-dependent carboxylation of coagulation factors II, VII, IX, and X and proteins C and S.
There are currently four NOACs available for patients with atrial fibrillation: dabigatran (Pradaxa®), rivaroxaban (Xarelto®), apixaban (Eliquis®), and edoxaban (Lixiana [Europe/Asia], Savaysa [Nth Am]. NOACs are the first-line treatment for most patients with venous thromboembolism (VTE) and for stroke prevention in atrial fibrillation (AF). NOACs have a lower propensity for drug and food interactions compared to vitamin K antagonists (VKAs) due to their individual coagulation proteins target and to the administration in fixed-dose without requiring routine coagulation monitoring.
Note that Vitamin K2 and D3 are essential for keeping calcium in the bones and out of the blood vessel walls, so a Vitamin K antagonist might not be a good thing for older patients.
Thank you, when a-fib was first diagnosed my cardiologist prescribed Predaxa and after a few months I had developed stroke like symptoms and was admitted. They found subdural bleeding and had to wait 24 hours for the predaxa to be out of my system for the brain surgery. During that time they thought I might not make it. But this was repeated later with Warfarin. It turns out that I was going to have brain bleeds on both types of blood thinner.
The solution after much trouble was to use a clamp on the LAA in the heart that produces blood clots thought to be the main cause of a-fib induced strokes.
Even later we learned that the main damage to my body parts was due to obstructive sleep apnea. Something that I have had for a long time but was only recently something that MDs had treatments for and thus did not prescribe sleep studies.
I would suggest that sleep apnea is a root cause type of ilness. May have caused the a-fib too, BTW, I still have a-fib, always will.