Posted on 07/24/2023 9:05:24 AM PDT by ConservativeMind
Clinical evidence suggests elderly individuals are at a higher risk of contracting viral infections. Quite notably, older people also have lower mean body temperatures.
A team of researchers has now been able to bridge the gap by linking higher body temperature with an increased infection-fighting capability of the gut microorganisms or "microbiota."
"High-heat-exposed mice raise their basal body temperature above 38°C, allowing them to produce more bile acids in a gut microbiota-dependent manner," remarks Dr. Takeshi Ichinohe.
The authors speculated that signaling of deoxycholic acid (DCA) from the gut microbiota and its plasma membrane-bound receptor "Takeda G-protein-coupled receptor 5" (TGR5) increased host resistance to influenza virus infection by suppressing virus replication and neutrophil-dependent tissue damage.
While working on these experiments, the team noticed that mice infected with the influenza virus showed decreased body temperatures nearly four days after onset of the infection, and they snuggled together to stay warm.
The team noticed similar results after switching the influenza virus with SARS-CoV-2 and the study results were also validated using a Syrian hamster model. Their experiments revealed that body temperature over 38°C could increase host resistance to influenza virus and SARS-CoV-2 infections. Moreover, they also found that such increase in body temperature catalyzed key gut microbial reactions, which in turn, led to the production of secondary bile acids. These acids can modulate immune responses and safeguard the host against viral infections.
"Our finding that reduction of certain bile acids in the plasma of patients with moderate I/II COVID-19 may provide insight into the variability in clinical disease manifestation in humans and enable approaches for mitigating COVID-19 outcomes," concludes Dr. Ichinohe.
The study reveals that high-body-temperature-dependent activation of gut microbiota boosts the serum and intestinal levels of bile acids. This suppresses virus replication and inflammatory responses that follow influenza and SARS-CoV-2 infections.
(Excerpt) Read more at medicalxpress.com ...
If I need my bile level elevated I will watch something featuring Joe Biden.
Didn’t we know this? It’s why our bodies produce a fever; to FIGHT infection.
The researchers just found this out ? It’s the reason we get fever when we have an infection. The body raises the temperature to inhibit viral activity.
Take vitamin C, vitamin D, and zinc balanced with copper as well as regular exercise to supercharge your immune system.
That’s why “hot toddies” work. They sweat it out.
“fever therapy” i.e. Coley’s toxins, was the premise for cancer “vaccine” treatment back in the old days.
That’s why I sit in a 103 degree hot tub every morning for an extended period.
106 outside today! I went out and watered the flowers in front and back then pittled around in the sun for about 45 minutes. Covered in sweat. Felt good.
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