Posted on 07/20/2023 4:05:05 PM PDT by ConservativeMind
Research found a connection between gut microbiota and distal symmetric polyneuropathy. The team finds a potential causal role of the gut microbiota in distal symmetric polyneuropathy symptoms.
Distal symmetric polyneuropathy (DSPN) is a common, progressive and debilitating neuropathy complication closely associated with diabetes.
While more than half of all patients with diabetes will develop diagnosable DSPN, no effective treatments are available.
The gut microbiota has been implicated in maintaining glucose homeostasis and affecting the nervous system through the gut-brain and neuroimmune-endocrine axes. Previous studies have demonstrated the impact of gut microbiota on neurodegenerative disorders in the central nervous system.
Significant differences in gut microbiota composition have been previously observed in diabetes patients with and without DSPN.
In a randomized, double-blind, placebo-controlled pilot clinical trial, FMT from healthy donors was conducted on 22 human patients with DSPN who responded poorly to conventional treatments. Compared to 10 patients who received a placebo, the results show a significant alleviation of DSPN symptoms after FMT, indicating a potential causal role of the gut microbiota in this disorder.
The study identifies key bacteria that may mediate the protective effect of the gut microbiota in DSPN using a genome-centric and guild-based approach. Two competing guilds of gut bacteria are identified: guild 1, associated with higher capacity in butyrate production and improved gut barrier integrity, and guild 2, associated with more genes in the synthetic pathway of endotoxin. Following FMT, an increase in guild 1 and a decrease in guild 2 are observed, aligning with the alleviation of DSPN.
The study suggests that beneficial effects of FMT on DSPN are not solely mediated through improvements in glycemic control or alterations in certain metabolites. Instead, reducing endotoxin production and increasing the capacity for butyrate production from the gut microbiota may improve gut barrier function and reduce systemic inflammation.
(Excerpt) Read more at medicalxpress.com ...
Chomo Joe tried a fecal transplant but the feces rejected him
Keep your shit to yourself.
I can’t imagine that is good either. I’ve seen plain yogurts which really should be called sugar flavored yogurts. The onl y yogurts I buy are plain normal unsugared made with whole milk. If I buy Kefir it is always plain.
I’ll bet the biggest customers for fecal transplants will be the ones who ran out and got the vax. Getting someone’s crap shoved up your ass doesn’t sound very scientific to me. Actually sounds like something that a fag would think up.
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