Non-invasive approach predicts retinopathy of prematurity earlier (Premies’ fingernail beds easily show eye problem)

Medical Xpress / Ann & Robert H. Lurie Children's Hospital of Chicago / The Journal of Pediatrics ^ | June 30, 2023 | Daniel York et al

[ConservativeMind]

Research promises to spare many premature infants from undergoing invasive eye exams to detect retinopathy of prematurity (ROP), the most common cause of preventable lifelong blindness in children in the U.S.

ROP is caused by an abnormal development of small blood vessels on the retina. Isabelle De Plaen, MD, and colleagues found that imaging the capillaries in the nailbed of preemies within the first month of life using a non-invasive technique, called nailbed capillaroscopy, can identify infants at high risk for developing ROP. This screening could eliminate the need to evaluate all premature infants with eye exams about a month later.

"Abnormal systemic vascular development starts much earlier than we thought. By measuring the nailbed capillary density soon after birth we can identify premature infants at higher risk for developing ROP long before it is detectable by an eye exam," said Dr. De Plaen.

"Earlier identification of these infants reduces the need to subject all premature babies to highly invasive eye exams. Our findings might also lead to the development of earlier preventive or therapeutic interventions for ROP and other complications of prematurity associated with maldevelopment of microvasculature."

ROP occurs in about 1/500–1/1,000 premature infants. It affects 33%–60% of babies with very low birth weight (less than 1,500g).

In the cohort of 32 premature neonates they studied, Dr. De Plaen and colleagues found that nailbed capillary density was higher in babies who later developed ROP. Microvascular density in the first month of life also correlated with the severity of ROP.

"The differences we found in microvascular density were most striking near birth, suggesting that perturbed microvascular development may begin in utero during the perinatal period, impacting organ microvascular development," said Dr. De Plaen.

[ConservativeMind]

Premies have a much higher likelihood of early eye problems. These can be potentially identified by examining the fingernail beds with a capillaroscope, as the same bad growth of blood vessels in the eye, occurs there, too.

This is easily performed.

[ConservativeMind]

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[UnwashedPeasant]

”It affects 33%–60% of babies with very low birth weight”

With a range that wide and that high, they should probably provide treatment to all babies with very low birth rate.