For vacation, I will drive to any destination that has a road leading to it.
Work pays me an ungodly amount at this point of my career so fast is better for work, so usually flights, especially here in Charlotte where it’s all direct everywhere. Time is my most valuable thing right now until I retire, so I’d rather not spend 10-40 hours (each way) in a car when I have a safer and faster option that’s not much more for just my wife and I (if I had 3-4 kids different story). Once I retire in ~2026, I may drive more for vacations, domestic ones at least ;)