Posted on 06/21/2023 9:06:57 PM PDT by ConservativeMind
Two novel approaches for the treatment of infections caused by antibiotic-resistant superbugs have shown efficacy and good clinical application potential in studies.
To date, a number of bacterial strains have been classified as superbugs, among which the hyper-resistant and hypervirulent Klebsiella pneumoniae is arguably the one which poses the greatest threat to human health. Prof. Chen Sheng discovered a newly emerged genetic variant of Klebsiella pneumoniae, namely the hyper-resistant and hypervirulent Klebsiella pneumoniae (CR-hvKP), which can cause untreatable and fatal infections even in healthy individuals.
Various studies in China showed that the mortality rate of CR-hvKP infection ranged from 25% to 45%.
Subsequent experiments revealed that inhibiting the onset of a cytokine storm could significantly reduce mortality among infected patients. The research team studied the therapeutic value of immunosuppressants such as Acetylsalicylic acid (ASA), and found that ASA can suppress the onset of a cytokine storm in infected mice. ASA, commonly known as Aspirin, is widely used to relieve mild to moderate pain and inflammation.
However, although ASA can protect patients against septic shock during CR-hvKP infection, this compound is unable to eradicate the pathogen. The research team therefore explored the use of a combination of ASA and other antibiotics in the treatment process and found that the therapeutic effect of ASA can be further enhanced by including an effective antimicrobial agent during treatment. However, since CR-hvKP exhibits resistance to almost all known antimicrobial agents, Prof. Chen's team adopted a "drug repurposing" approach.
The team successfully identified a drug called zidovudine, which is an anti-Human Immunodeficiency Virus (HIV) agent, which can act synergistically with the antibiotic rifampicin to eradicate CR-hvKP. It is expected that the zidovudine / rifampicin combination can be used alongside immunosuppressants to treat life-threatening CR-hvKP infections.
(Excerpt) Read more at medicalxpress.com ...
These are all cheap drugs.
Let Gates and Pfizer know so they can get those drugs outlawed this week
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