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Study: Using a diabetes medication after testing positive for SARS-CoV-2 reduces risk of developing long COVID by 40% (Metformin)
Medical Xpress / Lancet / The Lancet Infectious Diseases ^ | June 8, 2023 | Dr. Carolyn Bramante et al

Posted on 06/12/2023 7:26:43 AM PDT by ConservativeMind

Taking a two-week course of metformin, a safe and affordable diabetes medication after testing positive for SARS-CoV-2 leads to 40% fewer long COVID diagnoses over the following 10 months, compared to individuals taking a placebo, finds a study.

The long-term symptoms some people experience after SARS-CoV-2 infection, known as long COVID, are an emerging chronic illness potentially affecting millions of people around the world. Currently there are no proven treatments or ways to prevent long COVID, other than reducing the risk of infection in the first place.

This is the first phase 3 randomized controlled trial of a treatment for patients in the community that shows a medication can reduce the risk of long COVID when taken after testing positive for SARS-CoV-2.

Participants in the trial were not hospitalized, were at a higher risk of severe COVID-19 (overweight or obesity), over the age of 30, and had tested positive for SARS-CoV-2 within the last three days but had no known previous SARS-CoV-2 infection.

Metformin prevented over 40% of cases of long COVID in the trial with 6.3% (35/564) of participants given metformin reporting a long COVID diagnosis within 10 months of follow up, compared to 10.4% (58/562) of those receiving an identical placebo.

These findings reflect previously published results from this trial which found metformin prevented over 40% of emergency department visits, hospitalizations, and deaths due to COVID within two weeks of starting the treatment, compared to a placebo.

"Previous studies have found that metformin stops the SARS-CoV-2 virus from replicating in the lab, which is consistent with predictions from our mathematical modeling of viral replication, so that might be what is causing the reduction in both severe COVID-19 and Long COVID diagnoses seen in this trial," says co-author David Odde.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: covid; longcovid; metformin; offlabel
Metformin appears to stop the virus from replicating, along with any other blood sugar benefit it might provide.
1 posted on 06/12/2023 7:26:43 AM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 06/12/2023 7:27:14 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

In the long run Metformin will damage your kidneys. Lesser of two evils I guess.


3 posted on 06/12/2023 7:36:34 AM PDT by BigFreakinToad (Biden whispered "Don't Jump")
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To: ConservativeMind

Metformin with a good statin helps resensitize hormone resistant prostate cancer.


4 posted on 06/12/2023 7:59:16 AM PDT by Java4Jay (The evils of government are directly proportional to the tolerance of the people. )
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To: ConservativeMind

“Currently there are no proven treatments or ways to prevent long COVID, other than reducing the risk of infection in the first place.”

That’s one total BS lie.
The Front Line COVID-19 Critical Care Alliance (FLCCC)
https://covid19criticalcare.com/treatment-protocols/


5 posted on 06/12/2023 8:21:44 AM PDT by OftheOhio (never could dance but always could fight - Romeo company)
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To: OftheOhio

https://covid19criticalcare.com/protocol/i-recover-long-covid-treatment/


6 posted on 06/12/2023 8:30:46 AM PDT by OftheOhio (never could dance but always could fight - Romeo company)
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To: ConservativeMind; nickcarraway; ransomnote; Jane Long
Long COVID, my derriere. From 2021...

Metformin Suppresses Monocyte Immunometabolic Activation by SARS-CoV-2 Spike Protein Subunit

Wanna bet this is really about damage from CoupFlu vaxxes...?

7 posted on 06/12/2023 8:33:15 AM PDT by mewzilla (We will never restore the republic if we don't first secure the ballot box.)
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To: mewzilla

Maybe for both?

Good news, if so.


8 posted on 06/12/2023 8:35:50 AM PDT by Jane Long (What we were told was a conspiracy theory in ‘20 is now fact. Land of the sheep, home of the knaves)
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To: Jane Long

I have yet to see any evidence that what’s known as Long COVID exists.

But I’ll betcha all the people being treated for it have been vaxxed...


9 posted on 06/12/2023 8:38:10 AM PDT by mewzilla (We will never restore the republic if we don't first secure the ballot box.)
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To: Jane Long
Related, from last year...

Long Covid is a Social Construct Sequelae from viral infection are very real; our magical mythical shape-shifting Long Covid syndrome, not so much.

10 posted on 06/12/2023 8:39:16 AM PDT by mewzilla (We will never restore the republic if we don't first secure the ballot box.)
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To: mewzilla
Also from 2022...

How unreal is long-COVID? Mostly not real, mostly in their heads

11 posted on 06/12/2023 8:43:15 AM PDT by mewzilla (We will never restore the republic if we don't first secure the ballot box.)
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To: mewzilla

For a guy who has been here for 23 years you don’t have a clue, lol. I’ve had it as well as many people I know. Vaxed and unvaxed. Hell, my cat died of covid. There wasn’t any doubt in my mind. It was a bioweapon, anyone who has ever had it knows that to be true. One of the best written articles on covid period. https://www.theautomaticearth.com/2021/09/spartacus/


12 posted on 06/12/2023 9:05:07 AM PDT by OftheOhio (never could dance but always could fight - Romeo company)
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To: ConservativeMind

Bereberine is a natural form of metformin.... curious if it would have the same effect


13 posted on 06/12/2023 9:28:00 AM PDT by Katya (lacking in the feelings department, )
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To: ConservativeMind

humm.

if it’s so effective against the spike and the wide spectrum of ‘long’ virus symptoms, one immediately wonders why a large percentage of the people who got sars and actually died from the bio-weapon (not from deadly hospital protocols, or the bans on effective treatement), had diabetes as a co-morbidity. this i know from my own personal experience with a major medical center.

color me initially skeptical on this one. it’s the lancet so suspect on its face. have to check on it later.


14 posted on 06/12/2023 10:23:30 AM PDT by dadfly
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To: mewzilla

There are hundreds of thousands of people with long covid. I see them on facebook all time.

Long covid happens to people with compromised immune systems brought on by diabetes, pre diabetes, too much weight, auto immune diseases, moldy houses and previous flus.


15 posted on 06/12/2023 11:21:45 AM PDT by ckilmer (ui)
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To: ConservativeMind

.


16 posted on 06/12/2023 12:41:59 PM PDT by sauropod (“If they don’t believe our lies, well, that’s just conspiracy theorist stuff, there.”)
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To: ckilmer

Facebook...lol.
Per the Spartacus article:
“COVID-19 is more severe in those with specific comorbidities, such as obesity, diabetes, and hypertension. This is because these conditions involve endothelial dysfunction, which renders the circulatory system more susceptible to infection and injury by this particular virus.”

The real information is here:
“COVID-19 is not a viral pneumonia. It is a viral vascular endotheliitis and attacks the lining of blood vessels, particularly the small pulmonary alveolar capillaries, leading to endothelial cell activation and sloughing, coagulopathy, sepsis, pulmonary edema, and ARDS-like symptoms. This is a disease of the blood and blood vessels. The circulatory system. Any pneumonia that it causes is secondary to that.

In severe cases, this leads to sepsis, blood clots, and multiple organ failure, including hypoxic and inflammatory damage to various vital organs, such as the brain, heart, liver, pancreas, kidneys, and intestines.

Some of the most common laboratory findings in COVID-19 are elevated D-dimer, elevated prothrombin time, elevated C-reactive protein, neutrophilia, lymphopenia, hypocalcemia, and hyperferritinemia, essentially matching a profile of coagulopathy and immune system hyperactivation/immune cell exhaustion.

COVID-19 can present as almost anything, due to the wide tropism of SARS-CoV-2 for various tissues in the body’s vital organs. While its most common initial presentation is respiratory illness and flu-like symptoms, it can present as brain inflammation, gastrointestinal disease, or even heart attack or pulmonary embolism.”

The frontline doctors were very much aware of the month long cases of headache (my personal case) and developed a treatment protocol for it.
Once again, this is a disease of the blood and blood vessels. Speaking of blood clots...
Astonishing rise in atrial fibrillation says BHF
https://www.youtube.com/watch?v=Zoso8Um9P2M


17 posted on 06/12/2023 1:35:07 PM PDT by OftheOhio (never could dance but always could fight - Romeo company)
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To: mewzilla
In the General/Chat forum, on a thread titled Study: Using a diabetes medication after testing positive for SARS-CoV-2 reduces risk of developing long COVID by 40% (Metformin), mewzilla wrote:
Long COVID, my derriere. From 2021...

Metformin Suppresses Monocyte Immunometabolic Activation by SARS-CoV-2 Spike Protein Subunit

Wanna bet this is really about damage from CoupFlu vaxxes...?

Has to be.

18 posted on 06/12/2023 3:10:42 PM PDT by ransomnote (IN GOD WE TRUST)
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