Posted on 05/19/2023 5:44:40 AM PDT by ConservativeMind
A team led by Yu Leo Lei, D.D.S., Ph.D., have identified a mechanism in mice for how obesity affects some oral cancers' ability to escape from the immune system.
This study found that obesity helps to establish a type of tumor microenvironment that promotes tumor progression. How exactly this happens lies in the relationship between the saturated fatty acids, the STING-type-I interferon pathway, and NLRC3.
"We tend to think about the increased risks for gastrointestinal tumors, breast cancer, pancreatic cancer, and ovarian cancer when it comes to obesity," said Lei, a pathologist-immunologist and lead author of this study. "Multiple recent prospective cohorts involving millions of individuals from several continents revealed a previously underappreciated link between obesity and oral cancer risks."
"Myeloid cells in obese mice were insensitive to STING agonists and were more suppressive of T cell activation compared to the myeloid cells from leans hosts," explained Lei. This feature drove the loss of immune subsets that were crucial for anti-tumor immunity in the tumor microenvironment.
The team found that saturated fatty acids can block the STING pathway, which is induced by cytosolic DNA and promotes antigen-presenting cell maturation, by inducing a protein called NLRC3.
Lei says this is the first study establishing a mechanistic link between obesity with oral cancer immune escape. "We're excited about the translational implications," he continued.
Obesity is a common comorbidity in cancer patients. Two recent studies found that oral cancer patients who were on statins—medicines that lower cholesterol—showed improved overall and cancer-specific survival. "This study establishes a mechanistic link for those observations and highlights the potential of targeting fatty acids metabolism in remodeling the host anti-tumor immune response," said Lei.
(Excerpt) Read more at medicalxpress.com ...
Palmitate fat is ingested, as well as made, in our bodies, but we can create an overabundance of it through diet or lack of exercise, tipping the scales toward problems.
Now I worried that my overweight mouse might develop oral cancers.
Palmitate is also known as palmitic acid.
It is a saturated fatty acid.
METAL MERCURY FILLINGS IN YOUR TEETH ARE BAD.
232. TERI FRANKLIN, PhD, TOLD ME THAT I SHOULD HAVE ALL MY MERCURY AMALGAMS PULLED OUT AND REPLACED WITH COMPOSITES
https://robertyoho.substack.com/p/teri-franklin-phd-tells-me-that-i#details
Palmitic acid is heavily used in processed food, “convenience food,” junkfood, etc. A healthy diet would include very little of it. The study subjects were overweight because of their lousy diet, hence their cancer and the correlation with palmitic acid. Healthy animal-derived saturated fats are a crucial part of a healthy diet.
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