Posted on 04/26/2023 7:52:44 AM PDT by ConservativeMind
Renal hyperfiltration may be an underestimated risk factor for mortality, according to research.
Conventionally, diminished kidney function is linked to chronic kidney disease and elevated risk of mortality. Renal hyperfiltration (RHF), or increased kidney function, has been largely dismissed as a normal observation in the general population and an expected manifestation of diabetes mellitus where it precedes renal decline. The condition, devoid of clinical manifestations, remains unknown to general medicine and is primarily screened and managed within the context of diabetes mellitus.
Two recent studies reveal that the harms of RHF might be highly underestimated, independent of diabetes mellitus.
The first study suggests that the optimal limit to define RHF may be much lower than previously thought. By analyzing the risk of early death associated with high kidney filtration rates in 1,187 non-diabetic middle-aged Finnish men, the researchers found that a lower kidney filtration rate threshold could serve as a more precise measure for defining RHF.
This finding implies that the risk of early death related to RHF has been underestimated in the past.
The second study investigated the role of diabetes mellitus in the relationship between RHF and mortality. Using a cohort of 2,682 Finnish men, the researchers demonstrated that RHF is associated with an increased risk of mortality, irrespective of the effect of diabetes mellitus.
These two studies support evidence that RHF is a significant risk factor for early death and underscore the need to evaluate the potential benefits of integrating RHF screening into routine medical care, for both patients with and without diabetes. The authors call on the research community to further investigate RHF as an independent health condition and emphasize the need for a uniform and consensual definition of RHF, as higher-than-normal kidney function is not without consequences.
(Excerpt) Read more at medicalxpress.com ...
The studies describe a “very good” eGFR for one’s age as an indicator for a higher death rate. Seemingly, this is from a point in time it was once fairly lower, but I haven’t been able to discern that from the skimming of the two free studies, yet.
I will say some supplement changes a year ago made my eGFR go up nearly 15%. It centers around when my wife and I started taking GlyNAC, Taurine, and Urolithin A, and I took the test about seven months later.
I feel like they are trying to increase the population requiring some form of kidney treatment. I am not going to go into all the crap I went through regarding my weightlifting and supplementation and what they wanted to do to me. That they said I had moderate to severe kidney disease. They sent me to get kidney ultrasounds etc. which showed perfectly normal function. My urinalysis was also perfect. Everything was based on ratios in the bloodwork related to creatinin levels.
The bottom line is I stopped working out with weights and taking any creatine supplements for one month and my metrics were suddenly normal (which I tried to explain to them all along. That my supplementation and high muscle mass were impacting my ratios.)
Big pharma wants as many people as possible on these new CKD prescriptions, so they are getting the medical establishment to use these ratios indiscriminately.
My rule of thumb, is without any symptoms and good blood sugar and good urinalysis, anyone over 50 should ignore those stupid ratios.
Bingo! They started with almost everyone having "pre-diabetes" and now they're moving on to other things. Big Pharma is hard at work!
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