New group of drugs found to eliminate 'zombie' cells associated with cardiovascular disease (Senolytics - Dasatinib and Quercetin)

Medical Xpress / King's College London / The Journal of Cardiovascular Aging ^ | April 20, 2023 | Piotr Sunderland et al

[ConservativeMind]

I do take fisetin as a single dose, which is like a normal antioxidant, but not at the once-a-month mega dose size (14-15 pills) I once did.

The rest is correct.

[RummyChick]

I don’t take it at all. I did during Covid but something didn’t seem right.

I now know I have P450 issues which is why it probably was not sitting right with me. Once I get all the P450 issues resolved I will relook at Quercetin. By the way, if you have a no function CYP2D6 you may have an issue with tyramine in the brain not being metabolized to dopamine

Given my experience, I would say way more than 60% of the people here have no clue as to whether they have a P450 problem and most of the people here aren’t even aware of P450 issues.

Elvis fans should read this

https://www.practicalpainmanagement.com/pain/other/brain-injury/elvis-presley-head-trauma-autoimmunity-pain-early-death

[RummyChick]

Also, if you want to know what drug interactions you may have you can get a DNA test from Nebula and upload it to genetic genie and it will pull up SOME of the drug issues. It also shows issues with the transporters of drugs.

I have many screwed up genes that affect drug issues.

[RummyChick]

One more thing...if you are on warfarin your Doctor should have checked if you have issues. There are some drugs where Doctors will check but they may not do a panel test. It is expensive to get done through your Doctor’s office. Nebula does the whole body for a reasonable price.

[ckilmer]

I currently take quercetin and and fisetin. I’ll typically mix them with yogurt because I understand they are fat soluable.

This is the first I’ve heard of P450. But I’ve never had any problems with quercetin or any other supplement. So I have to assume that I don’t have the P450 issue.

I don’t know what this means: “if you have a no function CYP2D6”. I gather that you mean that if CYP2D6 is not functioning properly then I might have an issue with tyramine in the brain.

I don’t think that I have any cognitive problems beyond a bad case tinnitus.

Last year I did try to take Rapamycin. But it felt too me like it caused cognitive decline for a day. So I stopped.

[RummyChick]

There are a number of P450 enzymes. You can have defective from both parents or one parent.

I have 5 defective cyp2d6 SNPs. One of them is NO function. Meaning..ZERO function.

Anyone taking warfarin needs to be aware of the issue because there are multiple P450 issues.

It is a VERY complex issue.

If you look at drug tables Hydroxychloriquine wasn’t on the table...but now a new study shows it should be. So basically just because you think a drug is safe as it pertains to p40 issues..it might not really be safe.

https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and-drug-interactions-table-substrates-inhibitors-and-inducers

[RummyChick]

here is an example

if you have CYP2d6 that is ZERO function..and CYP3A that is also problematic but CYP2c8 that is normal...how do you adjust HCQ and what do you need to avoid if you P450 enzymes are whacked out

https://dmd.aspetjournals.org/content/early/2022/11/29/dmd.122.001018

This is so technical that I think regular Doctors may not be educated enough...you need a clinical pharmacology consult

[RummyChick]

btw, if you ever get your DNA tested you need to look at the CYP3A results.

Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat

https://pubmed.ncbi.nlm.nih.gov/1385058/

[RummyChick]

“Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetin”

https://pubmed.ncbi.nlm.nih.gov/21544726/

“Quercetin, a flavonoid, is an inhibitor of P-glycoprotein-mediated efflux transport, and its oxidative metabolism is catalyzed by CYP enzymes.”