Posted on 04/05/2023 12:19:51 PM PDT by ConservativeMind
Two key proteins linked to cell division can reliably predict disease recurrence in prostate cancer after radiotherapy treatment, according to new research.
Using an inexpensive and widely available technique in the clinic, the researchers evaluated a range of proteins in prostate tumor biopsies and determined that the phosphatase and tensin homolog (PTEN) and geminin proteins are key markers associated with cancer relapse after radiotherapy.
The team reported that patients with tumors showing loss of PTEN were almost three times more likely to experience recurrence than those with 'normal' PTEN. Similarly, the data showed a 70 percent increase in the likelihood of experiencing recurrence in patients with tumors that had a 10 percent increase in geminin.
Radiotherapy and surgery remain the gold standard treatments for localized prostate cancer. However, it is estimated that 20–30 percent of men will show signs of recurrence within five years of initial therapy, highlighting the need to improve treatments for these patients.
The researchers analyzed diverse proteins that are present in prostate tumors, and involved in important cancer-related cellular processes such as cell division, response to hypoxia (low oxygen), cell death, cell growth and inflammation, to assess if any of these markers could help to improve prediction of prognosis.
The team used the data from the samples to generate a model for estimating the prognostic value of each biomarker. They found that PTEN, a tumor suppressor that regulates cell growth and division, and geminin, a protein that inhibits DNA replication during cell division, could predict response to radiotherapy independently of other factors that are already used in the clinic.
The results from the study provided important reassurance that the effectiveness of the radiotherapy schedule was not impacted by tumor diversity. They also confirmed that the PTEN and geminin biomarkers could predict recurrence irrespective of radiotherapy regimen.
(Excerpt) Read more at medicalxpress.com ...
These tests can be done, today.
Biology is sexist, racist, and misogynistic
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If you have prostate cancer that has not spread outside the prostate, find a great prostate cancer urology surgeon who can do robotic surgery to remove it. With a great surgeon, you won’t have long-term urinary control or ED problems.
If you want a referral to just about the best in the world, PM me. This guy can also refer you to a urological surgeon in your area. Let me know where you live and I can get you a name. I did this for my brother.
The problem with radiation is that radiation never gets all the cancer. If a guy is really old, it might be an option if it is a slow-growing cancer, but why take a chance?
I’m guessing trans women will ignore this 🤣🤣🤣
Mid 2020, my partner had his annual physical and his PSA was about 10. He skipped the next year because he was trying to avoid Covid in medical offices. In mid 2022 his PSA was 21, and the doctor biopsied 16 locations in his prostate. All 16 had level 2 or 3 cancer in them. He was examined (x-rayed ?), whole body and they found no metastases. Last fall he had 6 weeks of radiation, and the 1st of 4 semi-annual anti-testosterone shots.
This Feb. he had the 2nd shot, and his PSA was 0.03. In March his PSA was 0.02. We are not happy with the thought he will have no sexual feelings for another year and 1/2. Would it make sense for him to have the surgery you describe? He has access to major urban health centers. I believe he was also retested for malignancy and nothing was found. Would he be better off just leaving the situation alone except for the anti-t shots. I give him a daily packet of vitamin, minerals and supplements.
During my cancer study research I found 2 valuable things aside from the IgG problem. A study of 9 common cancers found that all cancer tissues were deficient in Zinc, even when surrounding normal tissue was sufficient or well supplied with zinc. I also found that Astaxanthin which I have been taking successfully to improve my cataracts has possible cancer uses. It appears it increases apoptosis (normal cell death) in cancerous tissues while reducing the apoptosis rate in healthy tissue. So I have both my brother and my partner taking Astaxanthin and Zinc among other things.
He needs to get biopsy at a major cancer center like MD Anderson. He should also get a bone scan; not and X-ray. He may have gotten a bone scan and not an X-ray. The scans may look the same to an average person.
Based on what you posted, I’d get it removed. If the cancer is contained within the prostate a great surgeon and remove it without having long-term urinary or ED problems.
A huge benefit is that he would never have to worry about it again. He would need to continue with PSA checks and stay on Lupron for another 6 months. If his PSA were to increase in even the smallest amount, a 40 day proton radiation treatment would be best.
He needs to get biopsy at a major cancer center like MD Anderson. He should also get a bone scan; not and X-ray. He may have gotten a bone scan and not an X-ray. The scans may look the same to an average person.
Based on what you posted, I’d get it removed. If the cancer is contained within the prostate a great surgeon and remove it without having long-term urinary or ED problems.
A huge benefit is that he would never have to worry about it again. He would need to continue with PSA checks and stay on Lupron for another 6 months. If his PSA were to increase in even the smallest amount, a 40 day proton radiation treatment would be best.
If you live in Arkansas, MD Anderson is close enough to go there.
He can do a self-referral at www.MDAnderson.org
Don’t nee a doctor’s referral.
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