Most people tend to shoot high when firing down at a distance.
I hunt in pretty hilly country. My preferred load is a 180 gr. 30 caliber bullet I’m zeroed at about 150 yards. Shooting downhill, beyond that range, I can still hold pretty much dead on, and the bullet drop from added range is compensated for by the downward angle. Same applies to shooting uphill. but that is seldom the case.