Posted on 03/12/2023 9:31:32 PM PDT by ConservativeMind
A novel type of therapy, known as ANGPTL3 inhibitor therapy, was effective in lowering triglycerides in certain types of patients with severe hypertriglyceridemia (sHTG) who had a prior episode(s) of acute pancreatitis. sHTG is a well-established risk factor for recurrent episodes of acute pancreatitis.
This ANGPTL3 inhibitor therapy, the intravenous drug evicanumab-dgnb, inhibits two important regulators of lipoprotein metabolism. The research found that evinacumab reduced triglycerides by as much as 70% in people with sHTG who had at least some lipoprotein lipase (LPL) activity, the key enzyme in triglyceride metabolism.
However, in one of the three groups of sHTG patients with genetic mutations resulting in no LPL activity—a rare condition known as familial chylomicronemia syndrome—evinacumab was ineffective in lowering triglycerides. In the other groups, the triglycerides were reduced by a median of 65% to 82%.
Acute pancreatitis resulting from sHTG impacts 50 to 80 thousand people a year in the United States. It is a significant cause of morbidity, mortality, and reduced quality of life, as well as being a financial burden on the health care system, with patients often experiencing repeat attacks, requiring recurrent hospitalization. Therapeutic approaches to sHTG include weight loss, dietary counseling, lipid l-lowering medicines called fibrates, and omega-3 fatty acids, though none have proven sufficient.
Evinacumab was approved by the U.S. FDA in 2021 as an adjunct to other LDL-lowering therapies.
Researchers, also found that evinacumab treatment in patients with sHTG reduced levels of ApoC3, another important regulator of triglyceride metabolism, by 60%. Patients with sHTG typically have increased ApoC3 levels due to elevation of triglyceride-rich lipoproteins carrying ApoC3. Moreover, the class of ANGPTL3 inhibitors lower levels of apolipoprotein B, a large protein that serves as the backbone of LDL cholesterol and potentially the risk for heart disease.
(Excerpt) Read more at medicalxpress.com ...
I do note one treatment option—greatly lowering carbs, was not listed in the write up. That does drastically drop triglycerides, and it’s cheap and with few issues.
“I do note one treatment option—greatly lowering carbs, was not listed in the write up. That does drastically drop triglycerides, and it’s cheap and with few issues.”
LOL, at least you list the reason that it wasn’t included in the write-up: “it’s cheap and with few issues”
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