Posted on 03/04/2023 2:59:14 PM PST by ConservativeMind
A strategy of eight weeks of bedaquiline-linezolid is noninferior to a standard regimen for tuberculosis, according to a study.
Nicholas I. Paton, M.D. and colleagues conducted an adaptive, open-label, noninferiority trial involving participants with rifampicin-susceptible pulmonary tuberculosis. A total of 674 participants were randomly assigned to undergo standard treatment (rifampicin and isoniazid for 24 weeks with pyrazinamide and ethambutol for the first eight weeks) or a strategy involving initial treatment with an eight-week regimen, extended treatment for persistent clinical disease, monitoring after treatment, and retreatment for relapse; four participants withdrew consent or were lost to follow-up.
Four strategy groups were included with different initial regimens; noninferiority was assessed in two groups with complete enrollment, with initial regimens of high-dose rifampicin-linezolid and bedaquiline-linezolid.
The researchers found that a primary outcome event (composite of death, ongoing treatment, or active disease at week 96) occurred in 3.9, 11.4, and 5.8 percent, respectively, of those in the standard treatment group, the strategy group with an initial rifampin-linezolid regimen (adjusted difference, 7.4 percentage points; noninferiority not met), and the strategy group with an initial bedaquiline-linezolid regimen (adjusted difference, 0.8 percentage points; noninferiority met). The three groups reported similar incidences of grade 3 or 4 adverse events and serious adverse events.
"This treatment strategy provides a framework for the development of new, short, potent drug regimens and biomarkers for treatment monitoring to maximize cost-effectiveness and outcome benefit," the authors write.
(Excerpt) Read more at medicalxpress.com ...
They did have to continue treatment, if it didn’t resolve, but that would also be true of the 24 week form with other medicines.
The bedaquiline–linezolid treatment included INH, ethambutol, and pyrazinamide as well.
I strive to be noninferior.
.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.