Easy remedy. Just like Bush and Cheney were both living in Texas at the time. Cheney moved to Wyoming and the rest is history
The Cheney situation was different because he wasn't holding office at the time. If DeSantis were to leave the state, he'd have to give up the governorship.
Besides, Trump doesn't need DeSantis to win Florida. Maybe somebody like Greg Abbott (TX) could serve a similar purpose -- border state, strong on immigration, disabled?
-PJ