Posted on 03/03/2023 7:59:31 PM PST by ConservativeMind
Patients with severe eczema who were treated with the drug dupilumab experienced a reduction in symptoms and improved quality of life, according to a meta-analysis of several clinical trials.
The findings suggest dupilumab is a safe, effective treatment for cases of erythrodermic atopic dermatitis, or eczema, in which more than 90% of the body was affected.
Atopic dermatitis (AD) is the most common type of eczema, affecting more than 9.6 million children and about 16.5 million adults in the U.S., according to the National Eczema Association.
In the current study, investigators analyzed 209 patients with erythrodermic AD in six clinical trials. Patients given dupilumab treatment saw early and significant improvement of symptoms, including decreased itchiness and lower levels of atopic dermatitis biomarkers. Patients treated with dupilumab also reported a higher quality of life and fewer symptoms of anxiety or depression, according to the study.
"The question we have for many new therapies is, 'Will this work for the most severe patients?'" said Amy Paller, MD, the chair and Walter J. Hamlin Professor of Dermatology and a co-author of the study. "This group has the greatest risk for infection, comorbidities and even morbidity. So, we looked at the most severe patients, and the bottom line is they respond just as well to the treatment as milder cases."
Previously, treatment for AD has consisted of general immunosuppressant medications, Paller said. Because dupilumab is specifically targeted to block the cytokines responsible for inflammatory responses, it is generally considered safer for long-term use.
Side effects reported in the study included injection-site reaction, conjunctivitis and nasopharyngitis. Patients with erythrodermic AD were more likely to develop conjunctivitis compared to patients with milder cases, according to the study.
(Excerpt) Read more at medicalxpress.com ...
90+% body coverage by eczema would be exceedingly frustrating.
I used to have some eczema until I shifted to a Keto diet and cut out all the processed sugar. Who would have thunk it?
‘mab’s...’mub’s and ‘nib’s....
if you have clotting problems be very careful with these families of drugs...
I know personally..
They can be and are very effective.
They can also be very deadly
We managed to bootleg some Ivermectin for the eventuality that we would come down with the Wuhan Red Death.
The Ivermectin along with the cocktail of other vitamins, minerals, herbs and spices worked great. I noticed that it also cleared up my eczema. There’s some data online that it’s being utilized off-label for eczema treatment.
Later, I switched to a new doctor who actually knew something about medical freedom and got her to give me a script for Ivermectin. Of course, the insurance company refused it.
I’ve been using some of the horse paste version but haven’t figured out the dosage yet.
What was the dose for the prescription?
12mg once a week
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