Posted on 02/03/2023 2:43:00 PM PST by ConservativeMind
New data from a trial shows improved rates of survival and reduced risk of recurrence in patients taking osimertinib, a targeted therapy for non-small cell lung cancer (NSCLC). NSCLC is the most common type of lung cancer, and for patients diagnosed with more advanced disease stages, cases tend to recur.
The phase III ADAURA clinical trial assessed the safety and efficacy of osimertinib in patients with surgically removed (completely resected) stage IB-IIA NSCLC, who were previously treated with or without adjuvant chemotherapy.
The new data show there are ongoing benefits for patients with NSCLC taking osimertinib, including prolonged disease-free survival (DFS) over placebo, reduced risk of local and distant metastases (spread of tumor), and improved central nervous system DFS. These findings support the efficacy of adjuvant osimertinib in the patient population studied during the trial, researchers say.
The trial enrolled 682 patients with stage IB-IIA NSCLC, who were randomly assigned to receive 80 milligrams of osimertinib once daily or a placebo. Herbst and his research team found that fewer patients treated with osimertinib experience recurrence. Data also showed that fewer patients had distant metastases when compared to the placebo group.
The found that disease-free survival (DFS) over four years was 73% for the osimertinib group and 38% for the placebo group. And fewer patients who were randomly assigned osimertinib had disease recurrence (27%) than those in the placebo group (60%). The data from this study demonstrate prolonged DFS and reduced local- and distant-recurrence of symptoms, supporting osimertinib as a highly effective treatment in patients with resected EGFR-mutated stage IB-IIA non-small cell lung cancer.
"This therapy was well tolerated and prevented patients from developing metastasis to distant sites such as the brain, bone, and other areas of the lungs," Herbst said. "This has truly impacted the lives of our patients."
(Excerpt) Read more at medicalxpress.com ...
Good news. I think non-small cell lung cancer already had a better survival rate than small cell lung cancer.
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