One of the most exciting non-invasive, non-drug therapies that targets mitochondria function is photobiomodulation or PBM. Serveral peer reviewed studies have shown the using specific wavelengths of near-infra-red (NIR) light from LEDs held against the skin penetrate into tissues and reduce oxidative stress (ROS) in the mitochondria. This was used to treat hospitalized COVID patients and reduced their days in the hospital and serious effects including death over placebo treatments. It has also been used to slow cognitive decline in Alzheimer’s and Parkinson’s disease.
Here’s a video that discusses some of the science behind this.
https://youtu.be/a_8rE-71Y48?t=1046