Posted on 01/23/2023 1:22:04 PM PST by ConservativeMind
Scientists have identified biomarkers that could provide an early warning system for three common and dangerous pregnancy complications: pre-eclampsia, gestational diabetes, and a liver condition called intrahepatic cholestasis. All three conditions are dangerous; early diagnosis and treatment is key to preventing poor outcomes and lifelong consequences. Their causes are not fully understood, and nor is their connection to the gut microbiome, which is affected by pregnancy and pregnancy-related conditions.
A team led by Dr. Siqian Chen decided to investigate whether specific changes in the microbiome—detected using levels of short-chain fatty acids, metabolites which are produced following the fermentation of microbiota—could be used as biomarkers for pregnancy complications.
The team recruited 112 women who were divided into four groups: those who experienced healthy pregnancies, and those who were diagnosed with pre-eclampsia, gestational diabetes, or intrahepatic cholestasis. Chen and colleagues took medical histories and samples of blood, which were analyzed for levels of several short-chain fatty acids: acetic, propionic, butyric, isobutyric, isovaleric, and hexanoic acid.
They found several strong candidates for biomarkers among the short-chain fatty acids, particularly isobutyric acid. All three groups of women who experienced the specified complications showed elevated levels of isobutyric acid. Patients with gestational diabetes and pre-eclampsia also had elevated levels of isovaleric, acetic and propionic acid—the latter two potentially because of dyslipidemia, imbalance of lipids in the blood.
By contrast, women diagnosed with intrahepatic cholestasis had much lower levels of all the short-chain fatty acids except isobutyric acid, and their levels of hexanoic acid correlated strongly with their illness. The team suggested that the lower levels of short-chain fatty acids in general might be due to lower abundance of flora in the gut microbiome, while the hexanoic acid might be linked to related inflammation.
(Excerpt) Read more at medicalxpress.com ...
It appears ones known as “branched short-chain fatty acids (BCFA),” are isovaleric and isobutyric acids, and these are found in lower amounts in people who ingest more insoluble fiber, according to another paper I’ll put in the next post. These two acids are also believed to be markers of protein fermentation, which may also mean other negative substances are being made in the gut.
These fatty acids can be tested, but, honestly, it wouldn’t hurt to eat more dietary insoluble fiber to possibly prevent these problems.
The paper with the extra information I mentioned above:
An Overview on Fecal Branched Short-Chain Fatty Acids Along Human Life and as Related With Body Mass Index: Associated Dietary and Anthropometric Factors
https://www.frontiersin.org/articles/10.3389/fmicb.2020.00973/full
She tried to bail to Mexico on a plane but the feds had her passport. What was she thinking?
Living in a multi million dollar California mansion while waiting to report to the Federal Prison Camp, Bryan, in Texas...the most minimum security 'camp' in club fed.
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