Posted on 12/31/2022 10:17:00 AM PST by ConservativeMind
Lung cancer is a leading cause of death. Among all the cancers, lung cancer has one of the lowest five-year survival rates.
"Sarunashi" (Actinidia arguta) is an edible fruit cultivated in Japan's Okayama Prefecture. Using a mouse model, researchers have shown that sarunashi juice and its constituting component isoquercetin (isoQ) help prevent and reduce lung cancer.
A. arguta is one of the richest sources of polyphenols and vitamin C. Previously, the researchers had demonstrated the inhibitory effect of sarunashi juice (sar-j) on mutagenesis, inflammation, and mouse skin tumorigenesis. They had identified the components of A. arguta responsible for the anti-mutagenic effects as water-soluble and heat-sensitive phenolic compounds. Subsequently, the researchers proposed the polyphenolic compound isoQ as a constituting component with anticarcinogenic potential.
The team induced tumor growth in mice using NNK, a known cancer-causing compound present in tobacco products. Using a series of experiments and controls, the team studied the effects of sar-j and isoQ on lung tumorigenesis in mice.
The results were encouraging: The number of tumor nodules per mouse lung in the group that received NNK injections and oral doses of A. arguta juice was significantly lower than that in the group injected with NNK only. Moreover, the oral administration of isoQ also reduced the number of nodules in the mouse lungs.
Next, the team broke ground by discovering the likely mechanism of action. NNK and 1-methyl-3-nitro-1-nitrosoguanidine or "MNNG" are known mutagens—agents that trigger DNA mutations.
The researchers concluded that sar-j seems to mediate its antimutagenic effect by accelerating DNA repair.
Finally, using cell-based experiments, the team also showed that sar-j suppressed the action of "Akt," a key protein involved in cancer signaling. It is a known fact that Akt and an associated protein called "PI3k," get over-activated in several human cancers.
(Excerpt) Read more at medicalxpress.com ...
I was not able to find specific juices, but it may be possible to visit an Asian supermarket and find it labelled as “Monkey Pear,” “Siberian gooseberry,” “Siberian kiwi,” or “Hearty kiwi.” It’s not the normal kiwi we appear to get in stores.
Good excuse to grow them.
(As if I needed an excuse to grow anything, lol!)
I have been wanting to grow this for a long time. Completely hardy in Ohio. Widely available in the usual plant catalogs.
But it takes a lot of trellising for these rambling vines.
The best trellis I’ve found so far is a good sturdy fence. I’ve got one with 5ft welded wire mesh that’s been holding up volunteer grape vines for years now.
When my boys where in scouts long ago, one had an eagle project redoing a small local playground. I ended up with the old metal monkey bars. They make a great trellis for my hard kiwi vines
So there is a significant problem with mice that smoke?
the hardy kiwi vines do not ramble like regular kiwi vines.
Have had mine over ten years and they are pretty well behaved. they live on my monkey bars. it’s worth it to grow. just remember there are male and female plants needed for fruit.
Nice!
are you growing actinidia kolomikta or actinidia arguta?
Kolomikta is much smaller in vine length.
If arguta is behaving well then I will certainly grow it. The trellis system I read about was quite large and hefty, and was the reason I have been putting off planting some.
*
I am in zone 7 just FYI, and they grow well.
no problems or spraying in 10 years.
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