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High fat ketogenic diet envisioned as potential life-saving therapy to combat low platelets in cancer patients (Just 7 Days of Keto?)
Medical Xpress / Science Translational Medicine ^ | Dec. 29, 2022 | Delthia Ricks / Sisi Xie et al

Posted on 12/29/2022 8:12:42 PM PST by ConservativeMind

A high-fat diet may combat low platelet counts in the blood caused by chemotherapy, according to preliminary research.

Low platelets trigger a condition known as thrombocytopenia. Chemotherapy-induced thrombocytopenia is a severe complication in patients with cancer.

"We demonstrate that ketogenic diets alleviate chemotherapy-induced thrombocytopenia in both animals and humans without causing thrombocytosis," Xie added. In thrombocytosis, the body produces too many platelets.

Platelets are the tiny sticky disc-like cells—part of the blood supply—that clump together to form blood clots. When chemo destroys platelets, the result is thrombocytopenia, which can be dangerous.

Xie and colleagues found that a ketogenic diet can boost the production of ketone bodies in the liver, which in turn, have various biological effects, one of which is combating thrombocytopenia.

Ketone bodies are alternate energy sources when glucose is not readily available. Ketogenic diets, which emphasize foods high in fats and protein, dramatically lower calories from carbohydrate sources. There are three ketone bodies. The two main ones are acetoacetate and beta-hydroxybutyrate; acetone is the third and least abundant.

What Xie and colleagues found bordered on the spectacular: They noticed that the diet caused a change in the bone marrow, which resulted in a boost of circulating platelets. If these findings in animal models and a tiny group of human volunteers hold up to further scrutiny, a ketogenic diet could become a potential thrombocytopenia preventive for patients undergoing chemotherapy.

Switching to a ketogenic diet for 7 days boosted platelet counts within safe levels in 5 healthy volunteers. The scientists also examined retrospective data from 28 patients with cancer receiving chemotherapy and observed that 17 patients on a ketogenic diet had higher platelet counts and lower recorded episodes of chemotherapy-induced thrombocytopenia.

"Mechanistically, the ketogenic diet induced circulating β-hydroxybutyrate [and] increased histone H3 acetylation in bone marrow megakaryocytes," Xie wrote.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: ketosis; nutrition
It looks like keto can quickly change bone marrow into a healthier condition, without overshooting what is healthy.

In other words, it appears to normalize a bad situation with too few platelets being made.

1 posted on 12/29/2022 8:12:42 PM PST by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

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2 posted on 12/29/2022 8:13:14 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

How about trying a ketogenic diet without toxic chemotherapy? If I had cancer I would try IP6, curcumin, and a ketogenic diet. Cancers need sugar to grow, and a ketogenic diet should do a good job of starving a cancer.


3 posted on 12/29/2022 8:20:51 PM PST by devere
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To: ConservativeMind

This stuff is friggin’ FIERCE.

Sweetened with erithritol (sp?)

4 posted on 12/29/2022 8:39:40 PM PST by martin_fierro (< |:)~)
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To: martin_fierro

“This stuff is friggin’ FIERCE. Sweetened with erithritol (sp?)”

I have yet to find a keto ice cream close to its quality. Also note that the 7 grams is for the full pint, not per serving, and 7 grams is on their high side, as some of their flavors go down to 4 grams (including my favorite).


5 posted on 12/29/2022 8:46:41 PM PST by BobL
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To: ConservativeMind
Beef & pork fats good.

Manufactured fats are very bad.

6 posted on 12/29/2022 8:47:50 PM PST by Deaf Smith (When a Texan takes his chances, chances will be taken that's for sure.)
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To: martin_fierro

Rebel is great ice cream, and low carb!


7 posted on 12/29/2022 9:13:46 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: Deaf Smith

I was thinking that first while chowing down on the ribs I made yesterday afternoon for dinner. Though much of the fat had rendered out over the 3-1/2 hours involved, and so very tender, there was still enough for some good flavor!


8 posted on 12/30/2022 6:27:22 AM PST by FreedomPoster (Islam delenda est)
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To: ConservativeMind; martin_fierro

OK, you’ve convinced me to try.


9 posted on 12/30/2022 6:28:30 AM PST by FreedomPoster (Islam delenda est)
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