Cystic fibrosis drug could help treat pneumonia (Ivacaftor)

Medical Xpress / Charité - Universitätsmedizin Berlin / Science Translational Medicine ^ | Dec. 22, 2022 | Lasti Erfinanda et al

[ConservativeMind]

Pathogens such as SARS-CoV-2 and pneumococcus can cause severe pneumonia. If the airways then fill with fluid, the patient risks developing acute respiratory distress syndrome. Researchers have now discovered the molecular mechanisms that trigger fluid accumulation in the lungs.

This development also led them to discover a potential new therapy: A cystic fibrosis drug proved effective in their laboratory experiments, raising hope that this could be used to treat pneumonia regardless of the pathogen that caused it.

The study centered on the CFTR chloride channel, which scientists know is mainly found in the mucosal cells of our airways. There, it plays a major role in keeping our mucus thin so it can drain away easily. The researchers have now shown for the first time that cells in the blood vessels of the lungs also have CFTR and that its presence is drastically reduced in pneumonia.

In cystic fibrosis patients, a genetic mutation prevents the CFTR chloride channel from working properly in the mucosal cells of the airways, resulting in very viscous mucus. "Ivacaftor is a drug that increases the chances of the chloride channel opening, which helps the mucus to flow through the airways," says Dr. Erfinanda. "We wanted to see if it would also have a positive effect on the cells in the blood vessels of the lungs."

Ivacaftor did make the chloride channels more stable: it led to less degradation in the channels. Experiments on animal models showed the same effect: treatment with ivacaftor increased the probability of surviving severe pneumonia, reduced lung injury, and resulted in much milder symptoms and a much better general condition than without the drug.

"We really weren't expecting it to work so well," says Prof. Kuebler.

[ConservativeMind]

More information is available at the link.

This medicine appears to cost over $30,000, through GoodRX.

[ConservativeMind]

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[KTM rider]

so what is it ? Pneumonia or SARS COV2 or COVID 19 ? the only difference is the PCR test results (LOL)

kinda reminds me of how "global warming" became " climate change"

Through the miracle of Political Science and MSM propaganda, Colds and Flu has morphed into world changing COVID 19, it has an eerily similar effect on civilization that "climate Change" failed to produce.

greatest scam in world history

the pandemic that never happened