Posted on 12/21/2022 10:22:05 AM PST by ConservativeMind
A study conducted shows that anti-inflammatory drugs commonly taken by children may be associated with dental enamel defects (DEDs) currently seen in about 20% of children worldwide.
The authors investigated the effects of celecoxib and indomethacin, non-steroidal anti-inflammatory drugs (NSAIDs), alongside paracetamol.
Dentists have observed a sharp rise in the number of children seeking treatment for pain, white or yellow tooth spots, dental sensitivity and fragility.
Dental decay in the form of carious lesions appears sooner and more frequently in these patients, whose restorations are less adhesive and tend to fail more. Studies have shown they may have to replace restorations ten times more often over a lifetime than people with healthy teeth.
A specific coincidence aroused the researchers' curiosity most of all: the patients' ages. The first years of life, when DEDs form, are a period in which sickness is frequent, often with high fever.
"These diseases are typically treated with NSAIDs, which inhibit the activity of cyclooxygenase [COX, a key inflammatory enzyme] and reduce production of prostaglandin [which promotes inflammation]," said Francisco de Paula-Silva.
The researchers used rats to study the problem, as these animals have incisors that grow continuously. The rats were treated with celecoxib and indomethacin for 28 days, after which practically no differences in their teeth were visible to the naked eye. However, when the researchers began extracting, they found that the teeth fractured more easily.
Analysis based on imaging and chemical composition suggested that dental mineralization had been affected. The teeth contained below-normal levels of calcium and phosphate, which are important to dental enamel formation, and mineral density was low.
When the researchers looked for the reasons for this, they found alterations in proteins required for mineralization and cellular differentiation, showing that the drugs had indeed affected the composition of the dental enamel.
(Excerpt) Read more at medicalxpress.com ...
I would think this translates into adults having problems, as well, to some extent, but that wasn’t covered.
There’s a whole generation of children in China (now in their late 40’s and 50s) who were given tetracycline for everything when they were young - misuse of antibiotics was/is quite common in China.
So one sees many adults of that age with dark/grey teeth.
There are people here in their 80s and 90s who have “lines” across their teeth caused by one of the older mycins given to them when they were kids.
Those are commonly used in children??? Why? How? Those are some potent drugs that should not be commonly used in children. I got some of that for bursitis once and they only gave a few pills because of the potential damage they can do.
The best non-prescription anti-inflammatory is Bromelain. It’s a pinnapple extract. Take between meals. Works great.
Who/What is that?
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