Posted on 11/08/2022 7:12:26 AM PST by ConservativeMind
Levels of triglycerides are routinely measured as part of a preventive cardiology work-up and lowering triglycerides with several classes of drugs is common medical practice. Yet, in a major randomized trial of the novel drug pemafibrate, researchers found no reduction in rates of heart attack, stroke, or cardiovascular death over a five-year period, despite the drug lowering triglycerides by 26 percent compared to placebo.
PPARα agonists like fibrates are a class of drugs that reduce the level of triglycerides in the bloodstream through several mechanisms. Pemafibrate is licensed for use in some Asian countries; conventional fibrate drugs such as fenofibrate are approved for use around the world including the U.S.
The clinical trial, known as PROMINENT and sponsored by the Kowa Research Institute, Inc., included 10,497 patients who had type 2 diabetes, increased levels of triglycerides, and low levels of HDL-cholesterol—a group that had shown promising results in fibrate trials performed a decade ago. However, the PROMINENT trial primary endpoint of heart attack, stroke, need for coronary bypass or angioplasty, or cardiovascular death occurred in 572 participants randomly assigned to pemafibrate and 560 assigned to placebo, resulting in no statistical difference between groups. Pemafibrate, however, was generally well-tolerated and appeared to reduce rates of non-alcoholic fatty liver disease (NAFLD), an important condition among individuals with diabetes and obesity.
"We studied a patient population that is at high risk, and the best course of treatment for them remains an open question," said Paul Ridker, MD. "In contrast to studies of fibrates done a decade ago, our trial was done in an era when almost all participants were taking statin therapy, so the relevance of triglyceride lowering in contemporary medical practice remains uncertain."
Other trials of triglyceride lowering using alternative pathways (such as ApoCIII and ANGPTL3 inhibition) may help clarify these issues.
(Excerpt) Read more at medicalxpress.com ...
It is known handling your health well without a drug gets you much more assured success, but that’s a hill too many can’t successfully climb.
Statins are the greatest public health fraud since fluoride, eclipsed only by the jabs.
Amen!
“Statins are the greatest public health fraud since fluoride, eclipsed only by the jabs.”
But boy, do they ever push them.
Eat more eggs with all them vitamins and drink milk.
Triglycerides rise when a glycated liver fails to create healthy cholesterol balloons and place the triglycerides into the balloons. The triglycerides are left circulating through the bloodstream.
People need the cholesterol. The only viable solution is to stop the liver glycation. Stop ingesting alcohol and fructose.
Other information on this trial:
https://medicalxpress.com/news/2022-11-medicine-triglyceride-cvd-people-diabetes.html
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