The best chem and bio-chem profs I had as an undergrad were the toughest graders. We students knew that we had to know it all, and we gave it the extra measure (and really, really learned chem!)
I say just turn the students loose in the lab with a test that only asks them to make one organic molecule. KCN comes to mind.
I had a calculus instructor that way. Kids would walk into class and see him and then would leave and rearrange their schedules. I stayed with him and learned a lot. He was tough but good at teaching.
Nursing school was tough, any score below 80% on any quiz, test, or practical could get you thrown out of the program. Best case you had a corrective interview with the Dept. Head.
Worst case you were advised to go to another major.
My corrective interview came on a drug quiz concerning pediatric patients. I did pass in 2011 and have been a Nurse as a second career . ( My first was Aerospace, then Medical manufacturing engineering). The kind of Nursing I do now, Pediatric Outpatient, and no matter how long I have a patient, I review the Meds,dosage, administration times, and any other prior notes every shift that I start, because the standard is 100% in the real world.