Immune marker suPAR high in patients with heart failure, predicts risk and death (Better than current BNP test)

Medical Xpress / University of Michigan / Journal of Cardiac Failure ^ | Oct. 14, 2022 | Noah Fromson / Salim S. Hayek et al

[ConservativeMind]

For years, cardiologists have zeroed in on a hormone called BNP as a gold standard to determine if patients with heart failure are at risk of severe illness or death. It's released by the heart in response to when the cardiac tissue stretches due to pressure.

While the B-type natriuretic peptide, or BNP, is a "downstream" indicator of heart failure, researchers have been looking for biomarkers focused on what leads to heart failure.

A new study finds that levels of soluble urokinase plasminogen activator receptor, or suPAR, an immune protein known to play a role in kidney disease, are high in patients with heart failure and predict both heart failure and death. Beyond that, when suPAR is combined with BNP, the ability to predict such risks gets even stronger..

"BNP is marker that varies dramatically depending on the patient's fluid status. A more stable marker such as suPAR that is linked to the pathophysiology of heart failure could be more useful in identifying patients at higher long-term risk of disease progression or death."

Results reveal that suPAR levels were 17% higher in patients with heart failure than those without across the different subgroups, including patients with ischemic or non-ischemic cardiomyopathy. Levels of the protein carried more than two times risk for all-cause death, cardiovascular death and hospitalization for heart failure.

Additionally, when suPAR was found to be increased in patients without heart failure, they were more than 3.5 times more likely to develop the condition.

"SuPAR is also known to cause kidney disease—an important component of the pathophysiology of heart failure. This may explain why suPAR levels are strongly predictive of long-term outcomes in these patients."

A growing body of research links suPAR and poor outcomes for an array of conditions, from coronary artery disease to cancer and kidney dysfunction.

[ConservativeMind]

A common blood test not used for cardio issues can greatly benefit cardio patients by providing a more accurate understanding of potential, and current, heart disease.

[ConservativeMind]

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Bkmk

[trebb]

I hear checking for signs of the covid jab is also an accurate indicator of higher risk of heart failure...